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Found 67 clinical trials
GO2 PEEP Study: Bidirectional Oxygenation Valve in Postoperative Atelectasis

This is a single center, prospective, randomized controlled study, with the purpose of comparing a novel breathing device, called the GO2 device, which uses the concept of Positive End Expiratory Pressure (PEEP) to the standard breathing tool called the Incentive Spirometer (IS), thus improving respiratory dynamics of the postoperative patient.

bypass graft
  • 26 Jan, 2021
  • 1 location
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function

This is a study to see if an extra 2 weeks of continuous positive airway pressure (CPAP) in stable preterm infants in the neonatal intensive care unit (NICU) can cause increased lung growth and lung function in the infants as measured at 6 months of age by pulmonary function testing.

continuous positive airway pressure
respiratory distress
  • 03 Sep, 2021
  • 1 location
Pulmonary Disorders During Exercise in Patients With Obstructive Sleep Apnea

Purposes: 1. To investigate whether patients with severe obstructive sleep apnea syndrome (OSAS) are at higher risk for exercised-induced bronchoconstriction (EIB) due to baseline airway inflammation compared with age, gender, and body mass index (BMI)-matched controls. 2. To investigate the effect of 3-month continuous positive airway pressure (CPAP) therapy on …

continuous positive airway pressure
body mass index
  • 07 Nov, 2020
Assessing the Expression and the Activity of Rac1 Protein in the Airway Smooth Muscle of Asthmatic Patient

Asthma is a chronic inflammatory respiratory disease affecting 6 to 7% of the French adult population and responsible of 1000 deaths in France every year. Many anti-inflammatory treatments are available but few had been developed to target hyperresponsiveness.Investigators and searchers of the Institut du thorax have recently demonstrated the main …

pulmonary function test
dust mite
respiratory disorder
  • 08 Apr, 2021
  • 1 location
Translating an Efficacious Illness Management Intervention for Youth With Asthma

The propose of the study is to test the effectiveness of Reach for Control (RFC) as compared to Michigan MATCH to improve asthma symptoms, asthma management and lung functioning and to decrease ED visits and admissions for youth with poorly controlled asthma when integrated into hospital emergency departments and delivered …

  • 23 Apr, 2021
  • 1 location
Utility of Breath-holding Test in Systemic Sclerosis

This study aims to evaluate the utility of breath-holding test as a marker of pulmonary disease severity in patients with systemic sclerosis.

  • 27 Jan, 2021
  • 1 location
An Exploratory Study on the Treatment of Chronic Obstructive Pulmonary Disease With Autologous Bronchial Basal Cell Transplantation

Chronic obstructive pulmonary disease(COPD)is characterized by recurrent cough, expectoration and asthma, and eventually develop chronic pulmonary heart disease ,chronic respiratory failure and even death. The current clinical treatments for these patients are symptomatic treatment cannot solve the problem of the damaged lung structure fundamentally. Recent studies show that bronchial basement …

  • 04 Sep, 2021
  • 1 location
Randomized Placebo-controlled Analysis of Superior Laryngeal Nerve Block for Neurogenic Cough

Prospective randomized placebo-controlled trial assessing the efficacy of superior laryngeal nerve block for adults with neurogenic cough refractory to proton pump inhibitor as determined by improvement in validated cough severity questionnaires before and after injection of Marcaine and Kenalog compared to placebo (saline injection).

  • 09 May, 2021
  • 1 location
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect. We also hypothesize that our mechanistic studies will yield biomarkers that may herald disease recurrence …

raynaud's syndrome
stem cell transplantation
total body irradiation
  • 27 Jan, 2021
  • 2 locations
Increasing Physical Activity in COPD Through Rhythmically Enhanced Music

The VA cares for nearly one million Veterans with COPD at a cost of more than $5.5 billion annually. COPD profoundly impairs quality of life as it limits ability to work, to maintain physical exertion and to engage in social activities. Hospital-based rehab can decrease the need for inpatient and …

  • 28 Mar, 2021
  • 1 location