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Found 209 clinical trials
The Clinical Course of Interstitial Pneumonia With Autoimmune Features

Interstitial pneumonia with autoimmune features (IPAF) is a chronic interstitial lung disease (ILD) with some laboratoristic and/or clinical features of autoimmune disease, but without meeting criteria of connective tissue disease (CTD), and with no other causes of ILD. Despite recent efforts to standardize the diagnosis of IPAF, subjects with IPAF …

lung transplant
  • 20 Apr, 2022
  • 1 location
Association of Platelet Parameters With Bleeding Severity in Children With ITP (ITP-APPS)

Patients with severe immune thrombocytopenia (ITP) present with similarly low platelet counts but varying bleeding symptoms, making it difficult to predict the disease course and to decide on an appropriate treatment plan. In a single-center study, platelet parameters including the immature platelet fraction, the absolute immature platelet count , and …

autoimmune thrombocytopenia
platelet count
  • 19 Jun, 2022
  • 3 locations
A Prognostic Transcriptomic Signature for Chronic Hypersensitivity Pneumonitis (PREDICT-HP)

Up to 135 patients with hypersensitivity pneumonitis will be enrolled at 5 clinical centers across the United States. Patients will be followed for 24 months to determine if biomarkers in the blood can predict disease progression.

  • 19 Apr, 2022
  • 5 locations
Comparison of PD1+T Cell Expression in Peripheral Blood for Cardiac Function Prognosis in Patients With Acute MI

Comparison of high PD1+ T cell and low PD1+ T cell expression in peripheral blood for cardiac function prognosis in Patients with acute myocardial infarction

Accepts healthy volunteers
  • 13 Mar, 2022
  • 1 location
Natural History of Asthma With Longitudinal Environmental Sampling

Background Asthma is a serious clinical and public health problem. Researchers want to collect data to better understand how bacteria and other things in the environment can affect people's asthma. Eligibility Nonsmoking adults age 18 - 60 who have moderate to severe asthma and are not pregnant or breastfeeding. Design …

  • 28 Oct, 2022
  • 1 location
The Italian REgistry of Pulmonary Non-tuberculous mycobactEria (IRENE)

The Italian registry of pulmonary non-tuberculous mycobacteria (NTM) -IRENE- is an observational, multicenter, prospective, cohort study enrolling consecutive adult patients with either a NTM respiratory infection or NTM-Pulmonary Disease. The coordinating center is located at the Pulmonary Department of the Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. So …

  • 24 Feb, 2022
  • 1 location
Monocyte Phenotypic Changes in Heart Failure

There are many treatments that can improve how long and how well people live with heart failure when they are outside the hospital. However, the investigators know less about how to effectively treat hospitalized heart failure patients so that they do not have to return to the hospital after they …

Accepts healthy volunteers
heart failure
  • 23 Mar, 2022
  • 1 location
Romanian Kidney Transplant Cardiovascular Risk Registry

Kidney transplantation (KT) represents the best treatment for patients with end-stage kidney disease, being associated with improved outcomes and reduced mortality. Although the survival benefit with KT is mostly attributable to reduction in cardiovascular (CV) disease, KT recipients continue to remain at higher risk for CV-related morbidity and mortality when …

chronic renal failure
heart failure
myocardial infarction
  • 24 Jan, 2021
  • 1 location
Effect of Mepolizumab on Severe Eosinophilic Asthma (EMESEA)

Two parts: A:Case-control study including 15 healthy adult donors and 15 severe adult eosinophilic asthmatics selected for treatment with mepolizumab. B: A longitudinal cohort study,where the same patients once on mepolizumab treatment are followed over time (0, 4, 16 and 32 weeks). SCOPE: response to mepolizumab in severe adult eosinophilic …

Accepts healthy volunteers
  • 07 Oct, 2022
  • 2 locations