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Found 248 clinical trials
Clinical and Functional Effects of Cardiac Contractility Modulation in Chagas Heart Disease: a Randomized Study - Contractility - FIX-Chagas (FIX-Chagas)

Chagas disease is an endemic problem in Latin America, where millions of people are chronically infected with T. cruzi. Recently, it was assumed to have clinical and epidemiological relevance in several other countries due to migratory and globalizing social factors. CCC occurs in 30-50% of infected individuals, causing considerable morbidity/mortality …

  • 21 Sep, 2022
  • 1 location
Efferent Loop Stimulation Previous to Ileostomy Closure. Ileostim Trial. (Ileostim)

The loop ileostomy is an effective method used to bypass faecal contents and reduce the sequelae of possible anastomotic leakage. I t is most often performed after a low anterior resection indicated for lower-middle rectal cancer. A second operation is required for closure, with a morbidity of about 25%. Many …

cancer surgery
postoperative ileus
rectal anastomosis
ileostomy closure
  • 23 Apr, 2022
  • 1 location
A Comparison of Total Knee Replacement Patients Using the Zimmer-Biomet Persona Total Knee System With Different Inserts

As demand for knee joint arthroplasties surge, improving long term patients' satisfaction and implant survivorship has become of utmost importance, as patients seek not only to alleviate their condition, but also return to their usual daily activities and sports. Implant type and design plays an important role in this, with …

  • 31 Mar, 2021
  • 1 location
Precision Medicine for Sng/Pain Control

Patients have different response to different treatment modalities, and sore/pain medicine is no exception. In our experience, low-level laser (LLL), ultrasound, and prolotherapy can reduce sore /pain through different genetic pathway. Whether the therapeutic effect is controlled by the genetic variants of those sore /pain related genes or not, is …

  • 22 Dec, 2021
  • 1 location
Surgical Treatment of the Thoracolumbar Spine Fractures.

The thoracolumbar segment fractures are the most frequent along the spine, and surgical treatment is indicated in unstable fractures. Surgical treatment has been performed through the posterior fixation pedicle fixation systems, and where necessary complemented by decompression of the spinal arthrodesis and previous channel. Surgical treatment has been performed by …

ct scan
open surgery
  • 31 Jan, 2022
  • 1 location
Use of CBD Oil in the Treatment of Posttraumatic Stress Disorder

The overarching objective of the proposed project is to test the clinical efficacy of CBD in the treatment of post-traumatic stress disorder using a rigorous double-blind randomized clinical trial methodology. Participants (n=150) meeting full DSM-5 criteria for post-traumatic stress disorder (PTSD) will be randomized to one of 3 treatment arms: …

psychiatric disorder
  • 21 Feb, 2022
  • 1 location
Oxfordshire Sedentariness Obesity & Cardiometabolic Risk in Adolescents - a Trial of Exercise in Schools

Obesity is a major cardiovascular disease (CVD) risk factor that is rising fastest in children. Prevention of its damaging effects should begin earlier before they become irreversible. Pilot data identified novel markers of cardiometabolic dysfunction that may be better than body mass index at stratifying risk and as targets for …

  • 21 Aug, 2021
  • 1 location
Fighting Immunosenescence and Promoting Immunity by a Fasting-mimicking Diet Elderly.

Background: Immunosenescence is an aging-dependent phenomenon underlying age dependent deterioration in the function of the immune system, characterized by a decline in B and T cells with a relative increase in natural killer (NK) cells. Aging also promotes chronic inflammation accompanied by increased levels of pro-inflammatory cytokines. Both immunosenescence and …

  • 31 Oct, 2021
  • 1 location
CT Scan Compared to CXR and LUS in Pneumonia in the Elderly (OCTOPLUS)

Introduction: Pneumonia is a leading cause of mortality and a common indication for antibiotic in elderly patients. However, its diagnosis is often inaccurate. We aim to compare the diagnostic accuracy, the clinical and cost outcomes and the use of antibiotics associated with three imaging strategies in patients >65 years old …

purulent sputum
chest pain
  • 15 Mar, 2022
Pulmonary Embolism WArsaw REgistry (PE-aWARE)

Initiated in January 2008, The PE-aWARE (Pulmonary Embolism WArsaw REgistry) is an on-going single-centre prospective observational study of patients with confirmed acute pulmonary embolism (APE

  • 03 Feb, 2022
  • 1 location