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Found 243 clinical trials
RAMBLE - Rivaroxaban vs. Apixaban for Heavy Menstrual Bleeding (RAMBLE)

A large proportion of women with menstruating potential with newly diagnosed VTE or atrial fibrillation, treated with apixaban will have less menstrual blood loss than patients randomized to rivaroxaban.

anticoagulation therapy
fibrillation
anticoagulants
apixaban
rivaroxaban
  • 226 views
  • 27 Jan, 2022
  • 2 locations
The Pericapsular Nerve Block in Total Hip Arthroplasty (PENG)

In order to continue progressing towards outpatient total hip arthroplasty (THA), methods to adequately manage postoperative pain is of paramount importance. The purpose of this study is to quantify the effectiveness of the pericapsular nerve block in total hip arthroplasty in comparison to the fascia iliaca nerve block.

nerve block
hip arthroplasty
joint reconstruction
opioid
morphine
  • 0 views
  • 29 Apr, 2022
  • 1 location
Hemodynamic Effects of BPA at Rest and During Exercise in CTEPH (EXPERT-BPA)

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by obstruction of the pulmonary vasculature by residual organized thrombi, leading to increased pulmonary vascular resistance (PVR), progressive pulmonary hypertension, and right heart failure. Medical therapy and balloon angioplasty (BPA) are effective treatment alternatives in lowering pulmonary pressures and increasing pulmonary flow. The …

  • 4 views
  • 04 Oct, 2022
  • 2 locations
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Background Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new …

Accepts healthy volunteers
  • 106 views
  • 28 Oct, 2022
  • 1 location
Reduced Anticoagulation Targets in ECLS (RATE)

The objective of the RATE-trial is to study if reduced anticoagulation targets during ECLS diminish bleeding complications without an increase in thromboembolic complications or a negative impact on outcome.

aptt
anticoagulation therapy
renal function
heparin
  • 0 views
  • 22 Oct, 2021
  • 9 locations
Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients

The aim of the current pilot study proposal is to compare the use of the purified human fibrinogen concentrate (Fibryga, Octapharma USA) to cryoprecipitate for the treatment of cardiopulmonary bypass (CPB)-associated bleeding in pediatric cardiac patients in whom fibrinogen supplementation is indicated. The investigators' hypothesis is that fibrinogen concentrate will …

haemostasis
cryoprecipitate
fibrinogen
cardiopulmonary bypass
  • 0 views
  • 03 Nov, 2021
  • 1 location
Resolution Enhancement by a Supplemental Obstruction Lessening Venoactive Drug for Eight Weeks in Deep Vein Thrombosis (Resolve-DVT)

The RESOLVE-DVT study is a randomized single-center pilot study to determine the effects of hydroxyethylrutoside (Venoruton) on aspects of deep vein thrombosis (DVT) resolution associated with post-thrombotic syndrome (PTS). Based on these results, the investigators will estimate its potential as a preventive therapy for PTS. Eligible consenting patients who develop …

deep vein thrombosis
clot
deep venous thrombosis of lower extremity
venous thrombosis
blood clot
  • 0 views
  • 04 Oct, 2022
  • 1 location
Feeding With Indirect Calorimetry and Cycling in the Elderly Intensive Care Patient (FICE)

The aim of this study is to evaluate the effect of early exercise by cycle ergometry and early targeted feeding in reducing muscle atrophy and improve functional outcomes in the older critically ill patient.

critical illness
  • 6 views
  • 29 Oct, 2022
  • 1 location
Effects of Antagonistic Actions in Response to Trauma Exposure

The overarching objective of this study is to investigate the use of antagonistic actions as a treatment augmentation strategy for enhancing emotional processing during exposure to trauma-relevant stimuli. To accomplish this, participants (N = 84) reporting exposure to a combat, sexual assault, physical assault, or motor vehicle accident Criterion A …

sexual assault
traffic accidents
assault
  • 19 views
  • 29 Jun, 2022
  • 1 location
Age of Blood in Sickle Cell Transfusion

The Investigators hypothesize that older red cell units trigger phagocytosis and activation of circulating macrophages with a downstream immunomodulatory cascade and release of excess Non Transferrin Bound Iron(NTBI) that leads to increased rates of infection in adults with Sickle Cell Disease(SCD). To test this hypothesis, the study staff will perform …

hemoglobin s
blood transfusion
iron
sickle hemoglobin
transferrin
  • 16 views
  • 12 Mar, 2022
  • 2 locations