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Found 4637 clinical trials
Regional Citrate Anticoagulation for RRT During V-V ECMO

Anticoagulation is an essential component of all extracorporeal therapies. Currently locoregional citrate anticoagulation is the recommended technique for continuous renal replacement therapy (CRRT). However, low clearance of citrate restricts its use to blood flow up to 150 mL/min, preventing its use in ECMO. Renal replacement therapy (RRT) is commonly provided …

renal replacement therapy
acute respiratory failure
respiratory failure
  • 15 Dec, 2021
  • 1 location
Sutureless Closure for Primary Total Anomalous Pulmonary Venous Connection

The purpose of this study is to assess the percentage of pulmonary venous stenosis after TAPVC repair with sutureless closure.

  • 03 Jul, 2021
  • 1 location
Follow-up of Critical COVID-19 Patients

The study will follow COVID-19 patients who required intensive care after 3-6 months and one year after discharge from the ICU with functional level as well as organ function to assess recovery after COVID-19. Blood and urine will be collected for biobanking.

  • 01 Nov, 2021
  • 1 location
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline

The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Hypertonic Saline (HS) in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic …

Accepts healthy volunteers
  • 30 Apr, 2022
  • 1 location
Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's)

Multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of abatacept to achieve sustained glucocorticoid-free remission in patients with relapsing non-severe granulomatosis with polyangiitis (Wegener's) (GPA) . Participants will be randomized 1:1 to receive either abatacept 125 mg or placebo administered by subcutaneous injection once a week. Participants will continue …

granulomatous inflammation
anti-neutrophil cytoplasmic antibody
churg-strauss syndrome
  • 18 May, 2022
  • 20 locations
An Online Behavior Change Intervention to Promote Physical Activity in Adults With Asthma

The aims of this study are to investigate the effectiveness of an online behavior change (BC) intervention in increasing physical activity (PA) and reducing sedentary behavior in adults with asthma, as well as, in improving other clinical outcomes, in short and medium term. In this single-blind randomized clinical trial, patients …

  • 30 May, 2022
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions

Pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD) is associated with considerable morbidity and even mortality. Next to environmental risk factors, the investigators believe that there is an important role of genetic predisposition to develop PAH in CHD. There often is a discrepancy between the severity of …

genetic testing
vascular disease
ventricular septal defect
heart disease
  • 04 Jun, 2022
  • 1 location
REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study) (RELIEPH)

Background: For patients with out-of-hospital cardiac arrest (OHCA) at the intensive care unit (ICU), oxygen therapy plays an important role in post resuscitation care. During hospitalisation, a lot of these patients occur with pulmonary arterial hypertension (PAH). Currently a wide oxygen target is recommended but no evidence regarding optimal treatment …

  • 14 Jun, 2022
  • 1 location
Treating Tuberculosis Wasting With a High-protein Supplement (NUTRIATO)

Undernutrition at the time of diagnosis of active tuberculosis is a risk factor for increased mortality, and lack of weight gain during anti-tuberculous treatment has been linked to an increased relapse risk. The purpose of this study is to test the effect of Lacprodan® DI-8090 whey protein concentrate on anthropometric …

protein supplement
  • 16 Jun, 2022
  • 1 location
Effectiveness of Oral Management Strategies on Improving Oral Frailty and Oral Bacteria

The aim of this study is to examine the effectiveness of nurse-driven oral management for improvements of oral frailty, and oral bacteria pneumonia patients with oral frailty using a randomized controlled trial (RCT) design. Hospitalized pneumonia patients (N = 90) will be randomized into three groups (oral management, oral care, …

  • 19 Jun, 2022
  • 1 location