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Found 161 clinical trials
Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension

(dcSSc) or SSc-associated pulmonary arterial hypertension (SSc-PAH).

systemic sclerosis
pulmonary arterial hypertension
diffuse cutaneous systemic sclerosis
ifetroban
heart failure
  • 0 views
  • 04 Oct, 2022
  • 11 locations
Fetal Endoscopic Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH) (FETO)

The purpose of this research is to gather information on the safety and effectiveness of a new procedure called Fetoscopic Endoluminal Tracheal Occlusion (FETO).

pulmonary hypoplasia
diaphragmatic hernia
  • 2 views
  • 19 Sep, 2022
  • 1 location
Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension (REHAB-PH)

This is a Phase 2, single-center, randomized placebo controlled trial of famotidine (an H2 receptor antagonist) in adults with pulmonary arterial hypertension. The study will evaluate the safety

vasodilator
right heart catheterization
pulmonary vasodilators
hypertension
  • 55 views
  • 10 Feb, 2022
  • 1 location
Study of Angiogenic Cell Therapy for Progressive Pulmonary Hypertension: Intervention With Repeat Dosing of eNOS-enhanced EPCs (SAPPHIRE)

The SAPPHIRE clinical trial seeks to establish the efficacy and safety of repeated monthly dosing of autologous EPCs transfected with human eNOS (heNOS) in patients with symptomatic severe PAH

pulmonary arterial hypertension
prostaglandin
scleroderma
pulmonary arterial pressure
congenital heart defects
  • 11 views
  • 18 May, 2022
  • 6 locations
REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study) (RELIEPH)

lot of these patients occur with pulmonary arterial hypertension (PAH). Currently a wide oxygen target is recommended but no evidence regarding optimal treatment targets to minimise the prevalence of

  • 0 views
  • 14 Jun, 2022
  • 1 location
Spironolactone Therapy in Chronic Stable Right HF Trial (STAR-HF)

The purpose of this study is to evaluate the safety, tolerability and mechanistic effects of spironolactone, an aldosterone receptor antagonist, on sympathetic nervous system activity and right heart function and remodeling in patients with chronic right heart failure.

tapse
spironolactone
cardiac mri
diuretics
right ventricular failure
  • 67 views
  • 03 Mar, 2022
  • 1 location
Effect of Exercise and Respiratory Therapy on Right Ventricular Function in Severe Pulmonary Hypertension

(cardiac index) during exercise. Within the last decade, new disease-targeted medical therapies have been approved for treatment of pulmonary arterial hypertension (PAH). Sequential and upfront

heart failure
right heart catheterization
pulmonary arterial hypertension
pulmonary arterial pressure
  • 7 views
  • 04 Oct, 2022
  • 1 location
Assessment of Continuous Measurement of Transcutaneous CO2 for Evaluation of Alveolar Dead Space During Exercise (TEASE)

with Chronic Obstructive Pulmonary Disease (COPD), chronic heart failure (CHF), hyperventilation, Pulmonary artery hypertension (PAH), or interstitial lung disease (ILD)

exercise test
Accepts healthy volunteers
heart failure
interstitial lung disease
COPD
  • 2 views
  • 05 Jul, 2022
  • 3 locations
: Vascular Function in Health and Disease

Many control mechanisms exist which successfully match the supply of blood with the metabolic demand of various tissues under wide-ranging conditions. One primary regulator of vasomotion and thus perfusion to the muscle tissue is the host of chemical factors originating from the vascular endothelium and the muscle tissue, which collectively …

antioxidant
exercise test
stress test
pulmonary disease
nitric oxide
  • 0 views
  • 27 Sep, 2021
  • 1 location
Ob/Gyn Residency Podcast Curriculum

obstetrics rotations. Residents at HUP and PAH will be included. Post intervention questionnaires will be administered at the end of each block to assess resident satisfaction with their block as well as

  • 0 views
  • 01 Jul, 2021
  • 1 location