Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 155 clinical trials
The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia (SOPHA)

Treatment of O2 naïve patients with PAH will be included in this investigator-initiated trial (IIT) to assess efficacy and safety of oxygen substitution. Nocturnal oxygen substitution improved

hypertension
arterial occlusion
oximetry
hpah
apah
  • 0 views
  • 26 Jul, 2022
  • 1 location
A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension. (RIALTO)

To provide riociguat therapy to eligible patients with PAH originating from Bayer-sponsored trials with BAY63-2521/ Riociguat / Adempas® who are currently or recently treated in these trials

adempas
riociguat
pulmonary arterial hypertension
  • 2 views
  • 11 Jul, 2022
  • 1 location
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions

Pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD) is associated with considerable morbidity and even mortality. Next to environmental risk factors, the

hypertension
septal defect
heart disease
genetic testing
early diagnosis
  • 10 views
  • 04 Jun, 2022
  • 1 location
a Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients With Renal Insufficiency and Healthy Subjects

To evaluate the effect of renal insufficiency on the pharmacokinetics of TPN171H tablets after single dose oral administration, so as to provide basis for formulating clinical medication plan for patients with renal insufficiency; To evaluate the safety of TPN171H tablets in patients with renal insufficiency and healthy subjects

Accepts healthy volunteers
  • 0 views
  • 24 May, 2022
  • 2 locations
Effects of Treprostinil on Right Ventricular Structure and Function in Patients With Pulmonary Arterial Hypertension

In a group of patients with PAH treated with treprostinil, the current study aims to investigate the effect of treatment on RV structure and function; and correlate changes in RV structure and

endothelin receptor antagonist
walk tests
endothelin
treprostinil
nesiritide
  • 9 views
  • 15 Feb, 2022
  • 1 location
Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH (RIVERII)

This is an open-label, single-armed, prospective single-centre clinical study to evaluate the effect of riociguat on right heart size and function in patients with manifest PAH and CTEPH.

  • 0 views
  • 29 Apr, 2022
  • 1 location
Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension

(dcSSc) or SSc-associated pulmonary arterial hypertension (SSc-PAH).

hypertension
progressive systemic sclerosis
systemic sclerosis
rheumatism
heart failure
  • 0 views
  • 15 Jul, 2022
  • 11 locations
Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension (REHAB-PH)

This is a Phase 2, single-center, randomized placebo controlled trial of famotidine (an H2 receptor antagonist) in adults with pulmonary arterial hypertension. The study will evaluate the safety

right heart catheterization
vasodilator
hypertension
pulmonary vasodilators
  • 55 views
  • 10 Feb, 2022
  • 1 location
Study of Angiogenic Cell Therapy for Progressive Pulmonary Hypertension: Intervention With Repeat Dosing of eNOS-enhanced EPCs (SAPPHIRE)

The SAPPHIRE clinical trial seeks to establish the efficacy and safety of repeated monthly dosing of autologous EPCs transfected with human eNOS (heNOS) in patients with symptomatic severe PAH

pulmonary arterial pressure
prostaglandin
scleroderma
oxygen saturation
heart disease
  • 11 views
  • 18 May, 2022
  • 6 locations
Spironolactone Therapy in Chronic Stable Right HF Trial (STAR-HF)

The purpose of this study is to evaluate the safety, tolerability and mechanistic effects of spironolactone, an aldosterone receptor antagonist, on sympathetic nervous system activity and right heart function and remodeling in patients with chronic right heart failure.

hypertension
cardiac mri
spironolactone
diuretics
right ventricular failure
  • 67 views
  • 03 Mar, 2022
  • 1 location