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Found 157 clinical trials
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia (PinC)

Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect might contribute to the development of pulmonary hypertension after birth - in particular umbilical cord clamping before …

pulmonary hypoplasia
congenital diaphragmatic hernia
resuscitation
hypertension
umbilical cord clamping
  • 0 views
  • 12 Jul, 2022
  • 5 locations
A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension (MACiTEPH)

The purpose of the study is to evaluate the effect of macitentan 75 mg versus placebo on exercise capacity at Week 28 in participants with chronic thromboembolic pulmonary hypertension (CTEPH).

macitentan
  • 85 views
  • 24 Jul, 2022
  • 108 locations
Genetic Testing in Young Adults With Cancer Study

The overarching goal of our research is to define an evidence-based, sustainable approach to identifying and managing genetic risk among young adults with cancer and their relatives. Conventional practice leaves referral and testing decisions to mostly non-expert clinicians implementing complex guidelines at the point of care, leading to substantial under-utilization. …

genetic testing
cancer diagnosis
primary cancer
solid tumor
  • 0 views
  • 20 Oct, 2021
  • 1 location
Spironolactone for Pulmonary Arterial Hypertension

Background High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. In spite of recent advances in treatment, the

hypertension
pulmonary function test
medical therapy
walk tests
spironolactone
  • 11 views
  • 29 Jul, 2022
  • 1 location
Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension (T3PAH)

The main purpose of this clinical trial is to examine the feasibility and effects of tamoxifen in subjects with pulmonary arterial hypertension (PAH). The study will evaluate how well the drug

hypertension
tapse
walk tests
connective tissue disease
  • 82 views
  • 26 Apr, 2022
  • 1 location
Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension

or improvement in World Health Organization (WHO) functional class in humans with pulmonary artery hypertension (PAH).

hypertension
epoprostenol
diuretics
  • 3 views
  • 12 Jul, 2022
  • 1 location
ABI-009, an mTOR Inhibitor, for Patients With Severe Pulmonary Arterial Hypertension

mTOR activation has been shown to be relevant in the development and progression of pulmonary hypertension. Inhibition of mTOR has been shown to reverse or regress pulmonary hypertension in animal models. ABI-009 is an albumin-bound mTOR inhibitor with improved penetration in lung tissue.

pulmonary arterial hypertension
left ventricular end-diastolic pressure
pulmonary function test
congenital heart defects
primary pulmonary hypertension
  • 27 views
  • 26 Jan, 2022
  • 6 locations
Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

Background A heart catheterization is a diagnostic heart procedure used to measure pressures and take pictures of the blood flow through the heart chambers. Magnetic resonance imaging (MRI) fluoroscopy shows continuous pictures of the heart chambers that doctors can watch while they work. Researchers want to test this procedure with …

heart surgery
right heart catheterization
  • 20 views
  • 20 Jul, 2022
  • 1 location
The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia (SOPHA)

Treatment of O2 naïve patients with PAH will be included in this investigator-initiated trial (IIT) to assess efficacy and safety of oxygen substitution. Nocturnal oxygen substitution improved

hpah
cteph
hypertension
oximetry
pulmonary disease
  • 0 views
  • 26 Jul, 2022
  • 1 location
Respiratory and Physical Therapy in Patients With Associated Pulmonary Arterial Hypertension (APAH) With Congenital Heart Defects

patients with severe associated pulmonary arterial hypertension (APAH) as part of a congenital heart defect with / without Eisenmenger's Syndrome

hypertension
congenital heart defects
apah
  • 1 views
  • 21 Jul, 2022
  • 1 location