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Found 210 clinical trials
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ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy

Pulmonary Arterial Hypertension or PAH is a progressive condition for which there is no cure. Even with substantial pharmacologic advances in the modern treatment era, survival still remains

  • 99 views
  • 25 Mar, 2021
  • 1 location
None
Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test

monitor for changes in WTT app recorded 6MWT results following initiation of therapy in a treatment nave cohort of PAH participants Evaluate whether changes from baseline in 6 minute walk

  • 0 views
  • 28 Jan, 2021
  • 1 location
None
Long-Term Open Label Extension Study of Pemziviptadil (PB1046) in PAH Subjects Following Completion of Study PB1046-PT-CL-0004

, Open label Extension (OLE) Study for subjects with (PAH), having participated in double-blind Study PB1046-PT-CL-0004. The study will include adult subjects previously diagnosed with symptomatic PAH

hysterectomy
  • 93 views
  • 19 Sep, 2021
  • 15 locations
None
Right Ventricular Haemodynamic Evaluation and Response to Treatment

Mono-center Study to evaluate different multimodal functional parameter of the right ventricle in PAH-patients

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Gene Therapy Clinical Study in Adult PKU

This is a Phase 1/2, open-label, randomized, concurrently-controlled, dose escalation study to evaluate the safety and efficacy of HMI-102 in adult PKU subjects with PAH deficiency. Participants

deficiency
gene therapy
pah gene
  • 150 views
  • 21 Oct, 2021
  • 13 locations
None
Liver Cell Transplant for Phenylketonuria

Human phenylketonuria (PKU) results from phenylalanine hydroxylase (PAH) deficiency, and represents one of the most common and extensively studied single-gene Mendelian disorders in humans

deficiency
kuvan
psychological assessment
phenylalanine
sapropterin
  • 34 views
  • 16 Apr, 2021
  • 1 location
None
Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery

Considering that the cause of hemodynamic instability during OPCAB is closely related to right ventricular dysfunction with pulmonary artery hypertension, the use of inhaled iloprost (a

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation

increased death rates. Sildenafil (Revatio) has been approved by Health Canada in the treatment of pulmonary arterial hypertension (high blood pressure in the lungs) in patients with connective

  • 26 views
  • 08 May, 2021
  • 4 locations
None
Altitude Related Adverse Health Effects (ARAHE) in Patients With Precapillary Pulmonary Hypertension During 30h Exposure to 2500m

The interest of journeys to high altitude regions for recreational or professional purposes is increasing, also among potentially vulnerable groups including patients with chronic cardiopulmonary diseases such as pulmonary hypertension (PH). In Switzerland and many other regions worldwide, many settlements and alpine resorts are at altitudes above 1500m and alpine …

  • 0 views
  • 11 Nov, 2021
  • 1 location
None
Low-Dose Oral Imatinib for Scleroderma Pulmonary Involvement

The purpose of this study is to verify effect and tolerability of imatinib on pulmonary and skin fibrosis in patients affected by systemic sclerosis.

scleroderma
immunosuppressive agents
pulmonary involvement
fibrosis
cyclophosphamide
  • 33 views
  • 07 Nov, 2020
  • 1 location