Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 211 clinical trials
None
Acute Haemodynamic Study of TPN171H in Patients With Pulmonary Arterial Hypertension

This study is a phase IIa proof-of-concept study to evaluate the effect of single-dose TPN171H tablets on acute haemodynamic parameters in patients with pulmonary arterial hypertension.The trial is expected to include 60 patients, divided into 6 groups, according to 1:1:1:1:1:1 into the placebo group and the test drugs 2.5mg, 5mg, …

heart disease
hypertension
tadalafil
connective tissue disease
  • 0 views
  • 06 Nov, 2021
  • 9 locations
None
Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial Hypertension

arterial hypertension.

ambrisentan
digoxin
hypertension
diuretics
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH

This single-arm, Phase 3, 2-part, open-label, multicenter study aims to demonstrate the safety and tolerability of L606 in patients with PAH switching from a stable Tyvaso dose. The study will

  • 0 views
  • 24 Nov, 2021
  • 1 location
None
Microbiota Transplant Therapy for Pulmonary Arterial Hypertension: Early Safety and Feasibility Study

This pilot clinical trial will evaluate the initial safety and feasibility of intestinal microbiota transplantation (IMT) in patients with pulmonary arterial hypertension (PAH). This trial will

  • 0 views
  • 06 Dec, 2021
  • 1 location
None
Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAH

The purpose of this study is to determine if there is a greater effect to patients with advanced pulmonary arterial hypertension (PAH) by using a combination of two drugs, Treprostinil and

  • 0 views
  • 23 Jan, 2021
  • 1 location
None
ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy

Pulmonary Arterial Hypertension or PAH is a progressive condition for which there is no cure. Even with substantial pharmacologic advances in the modern treatment era, survival still remains

  • 99 views
  • 25 Mar, 2021
  • 1 location
None
Phase 2 Study to Assess Safety Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAH

This is a multi-center, randomized, double-blind, controlled, Phase 2 study to assess the safety, tolerability, and efficacy of pemziviptadil (PB1046) at the optimally titrated dose after 16 weeks of treatment. Subjects will be randomized in a 2:1 ratio to one of two parallel dose groups: a) high-dose group where PB1046 …

left ventricular end-diastolic pressure
body mass index
forced expiratory volume
connective tissue disease
immunodeficiency
  • 29 views
  • 05 May, 2021
  • 26 locations
None
(RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment)

Pilot study to determine the therapeutic effect of two prarallel groups treated with either Riciguat or Macitentan, evaluated by the change in systolic and diastolic RV function within 12 weeks after first drug intake in order to plan a larger Phase II study.

  • 26 views
  • 26 Jan, 2021
  • 3 locations
None
Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test

monitor for changes in WTT app recorded 6MWT results following initiation of therapy in a treatment nave cohort of PAH participants Evaluate whether changes from baseline in 6 minute walk

  • 0 views
  • 28 Jan, 2021
  • 1 location
None
Effects of DHEA in Pulmonary Hypertension

imaging at 18 weeks compared to placebo and to assess side effects and safety in pulmonary arterial hypertension.

hypertension
forced expiratory volume
pulmonary function test
pulmonary disease
ventilation perfusion lung scan
  • 17 views
  • 26 Jan, 2021
  • 1 location