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Found 156 clinical trials
Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation

The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.

  • 18 Apr, 2021
  • 1 location
New Orleans Pulmonary Hypertension Biobank (NO-PH Biobank)

Pulmonary hypertension (PH) is a serious condition characterized by a mean pulmonary artery pressure >=25mmHg on right heart catheterization (RHC). Despite advances in PH care, outcomes are still sub-optimal and further research is required into the pathobiology of the disease and development of biomarkers that can guide clinical care. The …

Accepts healthy volunteers
progressive systemic sclerosis
systemic sclerosis
right heart catheterization
  • 30 Jan, 2022
  • 1 location
Systemic Sclerosis and Jak Inhibitors : Emphasis on Macrophages

The Sclero-JAK project aims to assess the impact of a JAK1/2 inhibitor (ruxolitinib) on activation states of monocytes-derived macrophages (MDM) from systemic sclerosis (SSc) patients

  • 26 Mar, 2021
  • 1 location
Effectiveness of Bosentan Therapy in Patients With Systemic scleRosis and Progressive Digital ulcEr Disease. (CURE)

Digital Ulcers (DEs), are painful open sores on the fingers and toes and are due to limited perfusion of blood vessels in patients with Scleroderma. In particular, ulcers are caused by narrowing of the arteries, resulting in reduced blood supply to the fingers, causing pain and difficult to heal leaving …

progressive systemic sclerosis
raynaud's phenomenon
digital ulcer
  • 09 Apr, 2022
Is a History of Pre-eclampsia a Risk Factor for Vascular Phenotype in Women With Systemic Sclerosis?

Background Pre-eclampsia, defined by the association of an arterial hypertension and significant proteinuria after 20 weeks of gestation, complicates 1 to 2% of pregnancies in France. Its pathophysiology involves angiogenesis impairment, upregulated maternal systemic inflammatory response, activation of oxidative stress and endothelial dysfunction. In a recent Danish nation-wide cohort study, …

  • 28 Jan, 2021
  • 10 locations
Validation of a Non-invasive Assessment of Central Venous Oxygen Saturation by Using MRI

BOLD measured with MRI may be a useful noninvasive method for the assessment of right ventricular O2 saturation. A validation of this method against right heart catheterization has not been fully performed. Whether the method may have a diagnostic and prognostic role in chronic heart failure patients is unclear.

heart failure
chronic heart failure
  • 24 Dec, 2021
  • 1 location