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Found 8 clinical trials
The Effect of Inhaled Nitric Oxide (iNO) on Physiologic Dead Space in Patients With Mild Chronic Obstructive Pulmonary Disease

phenomenon called physiologic dead space. Mild COPD patients develop symptoms of intolerable breathlessness early in exercise compared with healthy individuals. Previous studies have shown that pulmonary

  • 0 views
  • 19 Sep, 2022
  • 1 location
Sildenafil for Liver Fibrosis in Adolescents and Adults After Fontan Operation

. Comparing with other oral pulmonary vasodilators, sildenafil is with less possibility of liver toxicity. Therefore, we will conduct a prospective, open-labeled, randomized-controlled study in at least 90

liver disease
fibroscan
venous pressure
fibrosis
elastography
  • 0 views
  • 14 Jun, 2022
  • 1 location
Milrinone in Congenital Diaphragmatic Hernia

Infants with congenital diaphragmatic hernia (CDH) usually have pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN) leading to hypoxemic respiratory failure (HRF). Pulmonary hypertension associated with CDH is frequently resistant to conventional pulmonary vasodilator therapy including inhaled nitric oxide (iNO). Increased pulmonary vascular resistance (PVR) can lead to …

pco2
mechanical ventilation
diaphragmatic hernia
pulmonary hypoplasia
vasodilator
  • 73 views
  • 03 Nov, 2021
  • 16 locations
Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension (SAPPHIRE)

This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.

interstitial lung disease
hypertension
sarcoidosis
chest radiograph
fibrosis
  • 14 views
  • 26 Feb, 2022
  • 1 location
Inhaled Nitric Oxide in Brain Injury

This study will evaluate the changes in respiratory mechanics following traumatic brain injury and determine the effect of inhaled nitric oxide on gas exchange.

mechanical ventilation
traumatic brain injury
coma
  • 6 views
  • 24 Mar, 2022
  • 1 location
Developing Hyperpolarized 129Xe MRI Biomarkers for Evaluation of Pulmonary Arterial Hypertension

In this study, hyperpolarized 129Xe MRI will be used to evaluate treatment efficacy in patients with pulmonary arterial hypertension (PAH). Participants will be imaged at 4 timepoints (baseline, 6 weeks post-therapy initiation, 12 weeks, and 18 weeks). Images will be analyzed to develop new biomarkers and to understand treatment effects.

  • 0 views
  • 19 Sep, 2022
  • 1 location
Pediatric Acute Respiratory Distress Syndrome Asia Study (PARDSProASIA)

the use of pulmonary (mechanical ventilation, steroids, neuromuscular blockade, surfactant, pulmonary vasodilators, prone positioning) and non-pulmonary (nutrition, sedation, fluid management

mechanical ventilation
assisted breathing
positive end expiratory pressure
assisted ventilation
pulmonary surfactant
  • 24 views
  • 27 Apr, 2022
  • 2 locations
Registry of Preterm Newborns With Severe Pulmonary Hypertension

The purpose of this prospective research registry is to collect data on treatment strategies and outcomes for premature newborns with severe pulmonary hypertension (PH).

  • 6 views
  • 30 Jan, 2022
  • 1 location