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Found 57 clinical trials
Xpert MTB/RIF Test in the Diagnosis of Pulmonary Tuberculosis

Currently in Taiwan, most clinicians use sputum smear and culture for the diagnosis of pulmonary tuberculosis (TB) and apply nucleic acid amplification (NAA) test in a selected manner. In 2013

  • 12 Nov, 2021
  • 5 locations
Evaluation of a Rapid Point-of-Care Serological Triage Test for Active TB

The performance of a new triage test for active tuberculosis (TB), SeroSelectTB, will be qualified in multi-centre randomised controlled trials at health-posts in South Africa, Tanzania and Ethiopia. Cost effectiveness evaluations will be conducted to support a value proposition to stakeholders and regulatory authorities, and to support commercialization requirements. Consenting …

  • 13 Oct, 2021
  • 1 location
A Clinical Risk Score for Early Management of TB in Uganda (PredicTB)

Although curative treatment exists, tuberculosis (TB) remains the leading cause of infectious mortality worldwide - often because people seek care for TB symptoms in highly resource-constrained clinics that cannot provide same-day diagnostic testing. The research team has developed an easy-to-use clinical risk score that, if implemented in these settings, might …

  • 21 Mar, 2022
  • 1 location
Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence

-negative adults with a diagnosis of drug susceptible pulmonary TB are planned to be included, recruited from TB clinics with established relationships to the trial sites at the start of their TB treatment

  • 07 Oct, 2021
  • 6 locations
Study to Check the Efficacy and Safety of Recombinant BCG Vaccine in Prevention of TB Recurrence

This is a Phase II/III trial with two groups of adults successfully cured of category 1 pulmonary TB receiving either VPM1002 or placebo. Single dose of VPM1002 / placebo will be administered to

Accepts healthy volunteers
  • 27 Feb, 2022
  • 9 locations
Early Bactericidal Activity of TBA-7371 in Pulmonary Tuberculosis

The purpose of this study is to assess the safety, early bactericidal activity (EBA) and pharmacokinetics of TBA-7371 in adult participants with rifampicin-sensitive tuberculosis and select dose regimen(s) for future studies.

sputum smear
direct microscopy
cervical cap
  • 09 Apr, 2022
  • 4 locations
Azithromycin as Host-directed Therapy for Pulmonary Tuberculosis

systemic inflammation in patients with drug susceptible pulmonary TB receiving standard treatment. To assess whether azithromycin on top of standard treatment in patients with drug susceptible

  • 19 Apr, 2022
  • 1 location
Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB

The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M. tuberculosis (MTB) with or without rifampin

acid-fast bacilli
platelet count
direct microscopy
  • 22 Oct, 2021
  • 1 location
Evaluation of Early Bactericidal Activity and Safety in Pulmonary Tuberculosis With WX-081

This is a multi-center, randomized, parallel, open-label, positive-controlled Phase 2 clinical trial, which aims to evaluate the early bactericidal activity, safety and tolerability of WX-081 in patients with drug-naive&susceptible and drug-resistant tuberculosis. Also the efficacy of WX-081 will be explored in participants with drug-resistant tuberculosis.

  • 22 Dec, 2021
  • 1 location
Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis

This study was a randomized controlled trial studying about acid-fast bacillus sputum conversion ratio from positive to negative of pulmonary tuberculosis patients between metformin with

  • 23 Mar, 2022
  • 1 location