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Found 58 clinical trials
Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence

-negative adults with a diagnosis of drug susceptible pulmonary TB are planned to be included, recruited from TB clinics with established relationships to the trial sites at the start of their TB treatment

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  • 1 views
  • 07 Oct, 2021
  • 6 locations
A Clinical Risk Score for Early Management of TB in Uganda (PredicTB)

Although curative treatment exists, tuberculosis (TB) remains the leading cause of infectious mortality worldwide - often because people seek care for TB symptoms in highly resource-constrained clinics that cannot provide same-day diagnostic testing. The research team has developed an easy-to-use clinical risk score that, if implemented in these settings, might …

  • 0 views
  • 21 Mar, 2022
  • 1 location
Evaluation of the Feasibility, Accuracy, and Effect of a Rapid Point-of-Care Serological Triage Test for Active TB (SeroSelectTB) in High Burden, HIV-endemic African Settings: a Multi-centre, Parallel-group, Randomised, Controlled Trial (SeroSelectTB)

The performance of a new triage test for active tuberculosis (TB), SeroSelectTB, will be qualified in multi-centre randomised controlled trials at health-posts in South Africa, Tanzania and Ethiopia. Cost effectiveness evaluations will be conducted to support a value proposition to stakeholders and regulatory authorities, and to support commercialization requirements. Consenting …

  • 3 views
  • 10 Oct, 2022
Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis

This study was a randomized controlled trial studying about acid-fast bacillus sputum conversion ratio from positive to negative of pulmonary tuberculosis patients between metformin with

  • 0 views
  • 23 Mar, 2022
  • 1 location
Evaluation of Early Bactericidal Activity and Safety in Pulmonary Tuberculosis With WX-081

This is a multi-center, randomized, parallel, open-label, positive-controlled Phase 2 clinical trial, which aims to evaluate the early bactericidal activity, safety and tolerability of WX-081 in patients with drug-naive&susceptible and drug-resistant tuberculosis. Also the efficacy of WX-081 will be explored in participants with drug-resistant tuberculosis.

  • 0 views
  • 22 Dec, 2021
  • 1 location
Safety and Efficacy Evaluation of 4-month Regimen of OPC-167832, Delamanid and Bedaquiline in Participants With Drug-Susceptible Pulmonary TB

This trial will assess the safety and efficacy of OPC-167832 combined with Delamanid and Bedaquiline in subjects with DS-TB administered for 4 months compared to rifampin, isoniazid, ethambutol, pyrazinamide (RHEZ) administered for 6 months

  • 0 views
  • 04 Oct, 2022
  • 7 locations
Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and Pyrazinamide

unsuccessful. However, recent data support a shortened regimen for mild and moderate pulmonary TB and simultaneous optimization of rifampicin (RIF) and pyrazinamide (PZA). This phase II clinical study

  • 0 views
  • 31 Aug, 2021
  • 1 location
Study on the Management Model of "Home Treatment" for Tuberculosis Patients

This project aims to standardize the management of "home treatment" for tuberculosis patients, improve the compliance of patients with treatment, reduce the risk of transmission, and study the establishment of "home treatment" management model for tuberculosis patients.

  • 0 views
  • 09 Feb, 2022
  • 1 location
EBA, Safety and Tolerability of Sanfetrinem Cilexetil

To evaluate the 2-week bactericidal activity, pharmacokinetics, safety and tolerability of sanfetrinem cilexetil in participants with rifampicin-susceptible pulmonary tuberculosis.

  • 0 views
  • 03 Jun, 2022
  • 1 location
Clinical Trial to Investigate Therapeutic Vaccine (RUTI) Against Tuberculosis (TB)

Prospective, randomized, double-blind, multicentre, placebo-controlled clinical phase IIb trial to evaluate efficacy of RUTI® vaccine in DS- (Drug-Sensitive) and MDR-TB (Multidrug-resistant) patients favourably responding to standard MDR-TB treatment. Time point of vaccination starts upon completion of 1 week of standard DS-TB treatment (cohort A), and another cohort of patients will …

  • 0 views
  • 07 Apr, 2022
  • 1 location