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Found 170 clinical trials
Featured trial
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved Ejection Fraction (HFpEF)

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved

  • 1014 views
  • 25 Mar, 2021
  • 1 location
A Phase 3, Prospective, Multicenter, Double-blind, Double-dummy, Randomized, Active-controlled, Parallel-group, Group-sequential, Adaptive, Event-driven Study to Compare Efficacy, Safety, and Tolerability of Macitentan 75 mg Versus Macitentan 10 mg in Patients With Pulmonary Arterial Hypertension, Followed by an Open-label Treatment Period With Macitentan 75 mg (UNISUS)

The purpose of this study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the time to the first clinical events committee (CEC)-adjudicated morbidity or mortality (M/M) event in participants with symptomatic pulmonary arterial hypertension (PAH) compared to macitentan 10 mg.

connective tissue disease
septal defect
hemodynamic evaluation
heart disease
left ventricular end-diastolic pressure
  • 390 views
  • 23 Oct, 2022
  • 181 locations
Effects of DHEA in Pulmonary Hypertension (EDIPHY)

The goal of this crossover trial is to determine whether the study drug dehydroepiandrosterone (DHEA) improves right ventricular longitudinal strain measured by cardiac magnetic resonance imaging at 18 weeks compared to placebo and to assess side effects and safety in pulmonary arterial hypertension.

pulmonary disease
pulmonary function test
hypertension
ventilation perfusion lung scan
forced expiratory volume
  • 17 views
  • 27 Apr, 2022
  • 1 location
Remote Exercise Testing in Patients With Pulmonary Hypertension

hypertension. Patients with pulmonary hypertension develop high blood pressure within the lungs, leading to a limitation in the amount of exercise they are able to perform. At diagnosis and follow-up

walk tests
exercise stress test
  • 0 views
  • 23 Apr, 2022
  • 1 location
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

This study compares L-arginine Versus Sildenafil as treatment for pulmonary hypertension in Children with Beta Thalassemia

sildenafil
beta thalassemia
hypertension
arginine
  • 27 views
  • 23 Feb, 2022
  • 1 location
Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study). (SATURN)

This study is a prospective, randomized, double-blind, study of H01 (Hymecromone) in adults with pulmonary hypertension (PH). The primary objective of this study is to evaluate the safety and

endothelin receptor antagonist
right heart catheterization
prostaglandin
endothelin
  • 0 views
  • 05 Jun, 2022
  • 1 location
A Prospective, Open-label, Platform Study for Long-term Follow-up of Participants Using Study Intervention in Pulmonary Hypertension Parent Studies (PLATYPUS)

The purpose of the study is to enable participants with pulmonary hypertension (PH) currently treated with study intervention(s) in a clinical study (parent studies [NCT03422328, NCT03904693 and

tadalafil
  • 0 views
  • 27 Oct, 2022
  • 9 locations
A Phase 2, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease

The primary objective of this study is to evaluate the safety and tolerability of treprostinil palmitil inhalation powder (TPIP) compared with placebo

sarcoidosis
treprostinil
  • 0 views
  • 25 Oct, 2022
  • 12 locations
PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation

particles that assist in damaging the cancer DNA. PET/MR as imaging biomarkers for cardiopulmonary dysfunction with a focus on Pulmonary hypertension (PH). Despite the measures taken to

cancer
  • 0 views
  • 08 Oct, 2021
  • 1 location
Visa-versa! Breaking Instead of Pushing the Pedals-A

concentric work, which results in huge training gain with a highly decreased oxygen demand and thus lower cardiovascular load. Pulmonary hypertension (PH) is a chronic condition associated with significant

pulmonary disease
exercise stress test
chronic thromboembolic pulmonary hypertension
heart failure
  • 0 views
  • 23 Mar, 2022
  • 1 location