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Found 17 clinical trials
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Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Combination therapy in pulmonary arterial hypertension (PAH) has been the subject of active investigation for more than a decade, with the benefit of targeting different pathways known to be involved in the pathogenesis of the disease. Adherence to prescribed therapy has an impact on clinical outcomes. Reducing the pill/tablet count …

  • 124 views
  • 02 Dec, 2021
  • 226 locations
None
Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery

selective pulmonary vasodilator) in patients undergoing OPCAB maybe beneficial for hemodynamic management. Previous research has showed that inhaled iloprost reduce pulmonary arterial pressure and pulmonary

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Altitude Related Adverse Health Effects (ARAHE) in Patients With Precapillary Pulmonary Hypertension During 30h Exposure to 2500m

), reduces exercise capacity and increases the pulmonary arterial pressure, which is of particular relevance for patients with chronic hypoxemic respiratory diseases including PH. On the other hand

  • 0 views
  • 11 Nov, 2021
  • 1 location
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The Impact of Sildenafil on the Pulmonary Circulation in Healthy Trained and Untrained Humans

during exercise. Reduced pulmonary arterial pressure in endurance trained participants despite endurance trained participants consistently displaying increased diffusion capacity/pulmonary perfusion at

  • 0 views
  • 24 Sep, 2021
  • 1 location
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Exercise Training in Patients With Cardioverter-Defibrillators

Exercise therapy has proven to be an effective additive therapy in patients with cardiovascular diseases. The prognostic value of physical activity is well established in patients with congestive heart failure. Therefore the investigators assumed that the population of patients with implantable cardioverter-defibrillators (ICD) with impaired left ventricular function may also …

implantable cardioverter-defibrillators
left ventricular dysfunction
ventricular arrhythmia
arrhythmia
heart failure
  • 24 views
  • 07 Nov, 2020
  • 1 location
None
4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension

PH or to monitor treatment effectiveness. Echocardiography is used as a screening tool to estimate systolic pulmonary arterial pressure (sPAP), but due various limitations, this technique is not

right heart catheterization
pulmonary arterial pressure
  • 0 views
  • 19 Nov, 2021
  • 1 location
None
THERAPY-HYBRID-BPA Trial

Riociguat could improve the exercise capacity and residual symptoms in patients with chronic thromboembolic pulmonary hypertension (CTEPH) even after normalization of pulmonary arterial pressure

right heart catheterization
riociguat
  • 2 views
  • 26 Jan, 2021
  • 1 location
None
Effect of Exercise and Respiratory Therapy on Right Ventricular Function in Severe Pulmonary Hypertension

vascular resistance and pulmonary arterial pressure, leading to right heart insufficiency. In later stages of the disease, the right heart is not able to further increase right ventricular contractility

right heart catheterization
pulmonary arterial pressure
pulmonary arterial hypertension
heart failure
  • 7 views
  • 11 May, 2021
  • 1 location
None
Outpatient Vasodilator Assessment Using Iloprost in Pulmonary Hypertension

This study will compare the clinical efficacy of inhaled iloprost as an invasive, selective vasodilator in the cardiac catheterization laboratory in patients with pulmonary hypertension to the gold standard of inhaled nitric oxide. It will also examine whether echocardiographic estimates of response to inhaled iloprost can predict responsiveness to invasive …

vasodilator
iloprost
nitric oxide
  • 1 views
  • 11 Jul, 2021
  • 1 location
None
The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia

Treatment of O2 nave patients with PAH will be included in this investigator-initiated trial (IIT) to assess efficacy and safety of oxygen substitution. Nocturnal oxygen substitution improved the 6MWD compared to placebo in one clinical trial in PAH patients. Due to the positive results in the treatment of patients with …

cteph
oximetry
hpah
pulmonary disease
hypertension
  • 0 views
  • 09 May, 2021
  • 1 location