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Found 213 clinical trials
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A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved Ejection Fraction (HFpEF)

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved Ejection Fraction (HFpEF)

  • 1004 views
  • 25 Mar, 2021
  • 1 location
None
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

This is a prospective, multicenter, open-label, randomized, controlled, parallel group, group-sequential, event-driven Phase 3 study to evaluate efficacy, safety and pharmacokinetics (PK) of macitentan in children.

hypertension
connective tissue disease
macitentan
heart disease
  • 178 views
  • 07 Oct, 2021
  • 107 locations
None
Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Combination therapy in pulmonary arterial hypertension (PAH) has been the subject of active investigation for more than a decade, with the benefit of targeting different pathways known to be

  • 124 views
  • 08 Oct, 2021
  • 224 locations
None
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

/M) event in participants with symptomatic pulmonary arterial hypertension (PAH) compared to macitentan 10 mg.

right heart catheterization
heart disease
macitentan 10 mg
macitentan
hypertension
  • 63 views
  • 07 Oct, 2021
  • 273 locations
None
A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (STELLAR)

The objectives of this study are to evaluate the efficacy and safety of sotatercept treatment (plus background PAH therapy) versus placebo (plus background PAH therapy) at 24 weeks in adults

  • 0 views
  • 24 Sep, 2021
  • 69 locations
None
Study of Sotatercept in Newly Diagnosed Intermediate- and High-risk PAH Patients

The objective of this study is to evaluate the effects of sotatercept treatment (plus background PAH therapy) versus placebo (plus background PAH therapy) on time to clinical worsening (TTCW) in

  • 0 views
  • 27 Oct, 2021
  • 3 locations
None
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension

from greater than or equal to (>=) 2 to less than () 18 years of age with Pulmonary Arterial Hypertension (PAH), by investigating the PK of selexipag and its active metabolite ACT-333679 in this

right heart catheterization
heart disease
hypertension
endothelin receptor antagonist
hpah
  • 34 views
  • 09 Oct, 2021
  • 94 locations
None
A Study of Selexipag Assessing Right Ventricular Remodeling in Pulmonary Arterial Hypertension by Cardiac Magnetic Resonance Imaging

The purpose of the study is to assess the effects of selexipag on right ventricular (RV) function in participants with Pulmonary arterial hypertension (PAH).

  • 0 views
  • 08 Oct, 2021
  • 45 locations
None
Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)

The objectives of the RELIEVE-PAH study are to obtain first-in-human experience with the study device in patients with severe pulmonary arterial hypertension, including evidence of initial

right ventricular failure
hypertension
connective tissue disease
  • 0 views
  • 27 Aug, 2021
  • 5 locations
None
Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)

This open-label extension study will evaluate the long-term effects of GB002 (seralutinib) in subjects who previously participated in a GB002 PAH study.

  • 0 views
  • 14 Oct, 2021
  • 3 locations