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Found 8 clinical trials
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Historically, medulloblastoma treatment has been determined by the amount of leftover disease present after surgery, also known as clinical risk (standard vs. high risk). Recent studies have shown that medulloblastoma is made up of distinct molecular subgroups which respond differently to treatment. This suggests that clinical risk alone is not …

tumor cells
corticosteroids
medulloblastoma
craniospinal irradiation
cancer
  • 144 views
  • 25 May, 2022
  • 1 location
Magnetic Resonance Imaging and Neuro-Psychological Testing In Cystic Fibrosis

CF is a complex, inherited illness that can affect many organs of the body. The investigators have found that some patients with CF have reported more problems with memory than would be expected at their age and that patients appear to be using memory strategies to overcome memory loss. The …

diagnostic procedures
fibrosis
  • 0 views
  • 10 Apr, 2022
  • 1 location
Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors: A Pilot Study

Children with brain tumors who have had radiation therapy are at risk for problems with attention, memory, and problem solving. Such problems may cause difficulty in school and daily life. Memantine, the drug being used for this study, is not yet approved for use in children by the U.S. Food …

low grade glioma
ganglioglioma
astrocytoma
human chorionic gonadotropin
cancer
  • 36 views
  • 24 Oct, 2022
  • 1 location
The Role of the Microbiota-gut-brain Axis in Brain Development and Mental Health

The role of the microbiota-gut-brain axis in brain development and mental health

Accepts healthy volunteers
  • 98 views
  • 03 Mar, 2022
  • 1 location
Screening Protocol for the Evaluation of Potential Research Subjects

involve any or all of the following procedures: (1) full physical examination and medical history; (2) psychiatric interview; (3) psychological testing; (4) electrocardiogram; (5) samples of blood, urine

drug abuse
Accepts healthy volunteers
psychological testing
  • 274 views
  • 07 Oct, 2022
  • 1 location
Longitudinal Study of Urea Cycle Disorders

Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on …

ornithine
hyperammonemia
deficiency
citrulline
arginine
  • 100 views
  • 23 Jan, 2022
  • 16 locations
BNT162b2 Messenger Ribonucleic Acid (mRNA) Covid-19 Vaccine in Cancer Patients on Active Treatment

In this Italian observational study the antibody titer reactogenicity to Pfizer Severe Acute Respiratory Syndrome (SARS) - Coronavirus (CoV-2) RNA vaccine in cancer patients under active antitumor treatment will be evaluated at 21 and 42 days and after 6 months. Furthermore patients safety will be monitored. Factors affecting immunogenicity (or …

primary cancer
cancer treatment
  • 0 views
  • 29 Jun, 2021
  • 1 location
Structural Stability of Carotid Plaque and Symptomatology

The purpose of the research is to understand structural plaque abnormalities that make a carotid plaque unstable and brake off (embolize) which would help to predict and treat individuals who are likely to suffer not only classic episodic major strokes but also cognitive impairment.

endarterectomy
stroke
atherosclerosis
  • 29 views
  • 11 Nov, 2021
  • 1 location