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Found 85 clinical trials
Digital Strategies for Patients With Chronic Dermatosis With Pruritus / Skin Picking Disorder

Almost 35% of patients treated to dermatosis have some psychiatric disorder. The aim of this study is to evaluate the prevalence and severity of skin picking disorder and other dermatosis, and also test the efficacy of an online-delivered cognitive-behavioral therapy to improve skin picking disorder severity.

  • 10 Feb, 2021
  • 1 location
Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders

Irritability and emotional dysregulation are recognized as serious aspects of psychopathology seen in in pediatric psychiatric patients. While various behavioral as well as psychopharmacological interventions have shown some efficacy in improving irritability and emotional dysregulation, there are no data determining the neurobiological mechanism of effect at the neural level. Previous …

  • 10 May, 2021
  • 1 location
Do Omega-3 Fatty Acids Have an Antidepressant Effect in Patients With Signs of Peripheral Inflammation?

In this study, the investigators will stratify depressed subjects a priori based on CRP levels to test the hypothesis that eicosapentaenoic (EPA) would be more efficacious to treat depression in subjects with high CRP levels compared to subjects with low CRP levels. Depressed subjects, with ongoing stabilized antidepressive treatment who …

omega-3 fatty acids
depressive episode
depressed mood
  • 24 Jan, 2021
  • 1 location
Bromocriptine for Patients With Schizophrenia and Impaired Glucose Tolerance

This is a multicenter open-label, pilot study to evaluate the safety and tolerability of bromocriptine, a dopamine D2/D3 receptor and serotonin 5-HT2C receptor agonist, as an adjunct to preexisting standard-of-care antipsychotic drug (APD) regimens in the management of APD-associated impaired glucose tolerance (IGT)/insulin resistance (IR). The ultimate aim of the …

type 2 diabetes mellitus
impaired glucose tolerance
  • 09 May, 2021
  • 1 location
A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease

The major purpose of this study is to assess the efficacy of CBD on motor symptoms of Parkinson's Disease (PD), and secondarily to study the safety and tolerability of CBD and other efficacy, particularly regarding tremor in PD. The study has been powered to detect a clinically significant reduction in …

motor symptoms
movement disorder
  • 03 Feb, 2021
  • 1 location
A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury

The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT) control condition, and to determine the rehabilitative utility of IOK for Veterans with PTSD. The first …

drug abuse
  • 27 Apr, 2021
  • 3 locations
Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings

Treating Opioid Patients' Pain and Sadness (TOPPS) focuses on the relationship of pain, depression, opioid and other substance misuse, and functioning. It has a structured agenda, uses behavioral activation, involves explicit and ongoing psychoeducation, and includes a behavioral health specialist (BHS) trained extensively in the nature of pain and opioid …

  • 26 Jan, 2021
  • 2 locations
Comparing Group Therapies for Veterans With Depression and PTSD

Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and PTSD. However, CBT is largely underutilized within Veteran Affairs Medical Centers (VAMCs) due to the cost and burden of trainings necessary to deliver the large number of CBT protocols. Transdiagnostic Behavior Therapy (TBT), in …

  • 13 Feb, 2021
  • 1 location
Impact of a Minimal Psychoeducational Intervention on Anxiety Among Hospitalized COVID-19 Patients in Denmark

Background: There is limited knowledge on the psychological implications of COVID-19 among hospitalized patients and their close relatives. Moreover, evidence-based psychological interventions targeting hospitalized COVID-19 patients and their relatives are currently lacking. Objective: To test a minimal psychoeducational intervention versus standard of care for reducing anxiety among hospitalized COVID-19 patients. …

anxiety reduction
psychological symptoms
  • 25 Jan, 2021
  • 1 location
Psychological Support Based on Positive Suggestions (PSBPS) on Mental Health Morbidity and Cognitive Function

The Researchers are trying to evaluate efficacy of a psychotherapeutic approach that can be applied to those who are critically ill. The daily approach in the Intensive Care Unit (ICU) is designed to provide patients with psychological support, reassurance, and explanations of where they are and what is happening to …

  • 26 Jan, 2021
  • 1 location