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Found 10 clinical trials
Biomarkers of Conversion Risk and Treatment Response in Early-Stage Schizophrenia

proton magnetic resonance spectroscopy (1H MRS)-based biomarkers for monitoring treatment response in early stages of SZ. In support of the viability of this overall objective is a large body of data

Accepts healthy volunteers
  • 03 Mar, 2022
Study of Neuroimaging Biomarkers of Social Cognition Deficits in Adolescents (Age 13-17) With Autism Spectrum Disorder and Effects of Gabapentin

(gamma-aminobutyric acid, GABA) neurotransmission in the social cognition deficits in ASD, and to develop proton magnetic resonance spectroscopy as a measurement of target engagement to measure the

neurodevelopmental disorder
pervasive developmental disorder
social interaction
  • 20 Apr, 2022
  • 1 location
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy

Background Glioma is a type of brain cancer. Some of these tumors have gene mutations. These mutations can cause a substance called 2-HG to build up in the brain. This makes the tumors more aggressive. Researchers want to better understand 2-HG buildup in the brain. They hope this can help …

measurable disease
brain tumor
MRI Scan
  • 11 May, 2022
  • 1 location
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression (LFMSBioMGeri)

The protocol involves functional Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy acquisitions immediately before and after Low Field Magnetic Stimulation treatment on two separate days in a sham controlled, randomized trial, in order to assess the physiologic effects of Low Field Magnetic Stimulation on brain function in a geriatric population …

magnetic resonance spectroscopy
depressed mood
functional magnetic resonance imaging
bipolar disorder
  • 27 Apr, 2022
  • 1 location
5-HTP and Creatine for Depression

This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression. Subjects will be randomized between 5-HTP + placebo, creatine + placebo, and 5-HTP + creatine, for 8 weeks. The ability of the interventions to affect biomarkers associated with …

  • 11 May, 2021
  • 1 location
Effects of a High EPA Multinutrient Supplement on Negative Affect in Young Adults. (NutriMOOD)

This is a 12-week-long, randomised, double-blind, placebo-controlled trial exploring the efficacy of a high-EPA multinutrient supplement in the management of sub-clinical anxiety and depression. The investigators focus on young and healthy, adult university students, who may otherwise not be eligible for pharmacological or cognitive behavioural therapy interventions.

behavior therapy
Accepts healthy volunteers
depressed mood
  • 05 Jun, 2022
  • 1 location
Evaluate the Efficacy and Safety of ADCV01 as an Add-On Treatment for Primary Glioblastoma Multiforme (GBM) Patients

This study is designed with open-label and randomized parallel group to evaluate the efficacy and safety of autologous dendritic cell vaccination (ADCV01) as an add-on treatment for primary glioblastoma multiforme

tumour resection
brain tumor
neutrophil count
tumor cells
  • 11 Apr, 2022
  • 3 locations
Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

functional magnetic resonance imaging (fMRI) scan, one proton magnetic resonance spectroscopy (MRS) and/or one C13 MRS scans, and up to two positron emission tomography (PET) scans. Participants will also

bipolar disorder
major depressive disorder
depressed mood
psychiatric disorder
  • 02 May, 2022
  • 1 location
Determination of Insulin-stimulated Hepatic Glucose Uptake by PET-CT Measurements (ISGU)

-body glucose uptake measures. Liver fat content and composition will be assessed by proton magnetic resonance spectroscopy (1H-MRS). Fasted De Novo Lipogenesis (DNL) will also be measured by deuterated

Accepts healthy volunteers
  • 05 May, 2022
  • 1 location
MR Imaging and MR Spectroscopy of HIV (HIV)

infection. According to pathological data, central nervous system (CNS) involvement is commonly found during the early phase of infection. In vivo proton magnetic resonance spectroscopy studies of HIV

Accepts healthy volunteers
  • 23 May, 2022
  • 1 location