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Found 88 clinical trials
European Alport Therapy Registry - European Initiative Towards Delaying Renal Failure in Alport Syndrome

The hereditary type IV collagen disease Alport syndrome inevitably leads to end-stage renal disease. Currently there are no therapies known to improve outcome. Our non-interventional, observational study investigates, if medications such as ACE-inhibitors can (1) delay time to dialysis and (2) improve life-expectancy within three generations of Alport-families in Europe.

Accepts healthy volunteers
  • 05 Jun, 2022
  • 1 location
The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry) (FOrMe)

In a monocentric, later multicentric prospective approach the FOrMe registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry) aims to generate a longitudinal cohort of 150 pediatric cases of idiopathic nephrotic syndrome and 350 adult cases of biopsy-proven Minimal Change Disease (MCD) or Focal and Segmental Glomerular Sclerosis …

minimal change disease
nephrotic syndrome
kidney transplant
  • 07 Feb, 2022
  • 1 location
Urinary Biomarkers in Paediatric Kidney Transplantation (pKTx)

This study aims to test and validate the panel of study urinary biomarker to assess whether (1) reference values differ between paediatric renal transplant patients, patients with chronic kidney disease stage IV and V (CKD IV-V) and children without any disease, (2) characteristic changes in concentration profile may be observed …

cystatin c
Accepts healthy volunteers
chronic kidney disease (ckd)
hormone replacement therapy (hrt)
renal replacement therapy
  • 22 Mar, 2022
  • 1 location
Sequelae of Sars-CoV-2 Infections

By the end of 2019 a new coronavirus, named SARS-CoV-2, was discovered in patients with pneumonia in Wuhan, China. In the following weeks and months the virus spread globally, having a tremendous impact on global health and economy. To date, no vaccine or therapy is available. Severe courses of the …

coronavirus infection
  • 09 May, 2021
  • 1 location
Immune Checkpoint Inhibitors Nephrotoxicity

In recent years, immunotherapy has been postulated as one of the most effective strategy in the fight against cancer. The greatest success in this field has been achieved through the inhibition of molecules involved in the brake of the adaptive immune response. The compounds capable of blocking the action of …

  • 04 Oct, 2022
  • 2 locations
Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Background People with sickle cell disease (SCD) have problems with their heart, brain, kidneys, liver, and lungs as they age. These problems may improve after transplant. Researchers want to learn how and why this happens. Objective To study the benefits of treatments that are intended to cure SCD. Eligibility People …

  • 02 Oct, 2023
  • 1 location
Sleep and Insulin Resistance: The Impact of Gender Affirming Hormone Therapy in the Adolescent Transgender Population (ATP)

Disordered sleep is a health issue with significant impacts on physical and psychological well-being that has increased in prevalence, but its impact on transgender adolescents has not been fully quantified. While there is found to be an impact of sex steroids on sleep, and sex-dependent differences in the impact of …

Accepts healthy volunteers
  • 24 Oct, 2022
  • 1 location
Omeprazole and Famotidine in Chronic Dysfunction of the Transplanted Kidney

The aim of the study is to compare the effect of omeprazole and famotidine on the risk of developing chronic renal transplant dysfunction. For the study, it is planned to qualify 36 stabilized adult patients from 1-24 months after kidney transplantation, who will receive p.o. the standard, most commonly used …

  • 20 Oct, 2021