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Found 106 clinical trials
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AURONA - An Open-Label Dose-Exploration Cohort Study Evaluating the Efficacy and Safety of Voclosporin in Achieving Complete or Partial Remission of Proteinuria in Subjects with Focal Segmental Glomerulosclerosis

proteinuria after 24 weeks of therapy in subjects with focal segmental glomerulosclerosis (FSGS). - To assess the safety and tolerability of VCS over 24 weeks in subjects with

  • 76 views
  • 23 Nov, 2020
  • 2 locations
featured
ALN-CC5-005: A Phase 2, Randomized, Double-blind, Placebo-controlled Study of Cemdisiran in Adult Patients with IgA Nephropathy

; blood pressure, kidney function, degree of hematuria, and proteinuria will be measured. Patients will not receive study drug (cemdisiran or placebo) during this time. The standard of care is

  • 99 views
  • 23 Nov, 2020
  • 2 locations
featured
Kidney Disease in Type 2 Diabetics

Kidney Disease in Type 2 Diabetics

  • 1306 views
  • 25 Mar, 2021
  • 1 location
A Crossover Pilot Study of the Effect of Amiloride on Proteinuria

This cross-over study is designed to test the hypothesis that amiloride will reduce urinary protein excretion and protect the kidney from rapid progression in proteinuric kidney disease.

glomerular filtration rate
nephropathy
  • 3 views
  • 23 Jan, 2021
  • 2 locations
An Open Labeled Pilot Study of Atorvastatin in Systemic Lupus Erythematosus

The aim of this study is to to determine whether atorvastatin 40mg per day is effective in the treatment of SLE.

proteinuria
immunosuppression
immunosuppressive agents
nephritis
  • 19 views
  • 07 Nov, 2020
  • 1 location
Salvage Therapy With Sunitinib Docetaxel and Platinum on Metastatic or Unresectable Non Small Cell Lung Cancer

Sunitinib shows anti-tumor activity in a variety of human non-small cell lung tumor ex vivo models. Many Phases II and III clinical trials of sunitinib in several solid tumors are completed or still ongoing. So far, the efficacy of sunitinb has been confirmed by the phase III trial for imatinib-resistance …

neutrophil count
growth factor
bevacizumab
docetaxel
stage iv non-small cell lung cancer
  • 2 views
  • 08 Nov, 2020
  • 1 location
Feasibility of Low Energy Diet in HFpEF and Type 2 Diabetes

Open, Single arm intervention, feasibility study

  • 0 views
  • 23 Jan, 2021
  • 1 location
Comprehensive Management of Diabetic Patients With Renal Impairment : Impact on Blood Pressure and Glycemic Control

Diabetes is the leading cause of end-stage renal disease in developed countries. Hypertension and metabolic control are known to affect the progression of renal deficiency and patient's outcome. Our project aims at implementing a multidisciplinary and systematic approach of diabetic patients with renal deficiency, and at evaluating the impact of …

renal failure
diabetes
hypertension
nephropathy
  • 10 views
  • 07 Nov, 2020
  • 1 location
Impact of Conversion From Tacrolimus to Sirolimus in African American Renal Transplant Recipients

The objective of this study is to examine the effect on allograft function and histology of converting African American renal transplant recipients with chronic allograft nephropathy (CAN) from a tacrolimus-based regimen to a sirolimus-based maintenance immunosuppression regimen. The investigators hypothesize that the conversion from tacrolimus to sirolimus in African American …

  • 20 views
  • 08 Nov, 2020
  • 1 location
Azithromycin in Post Diarrheal Haemolytic and Uremic Syndrome

Post diarrheal hemolytic and uremic syndrome (D+HUS) is the first etiology of acute renal failure in children less than 5 years old in France. Previous works highlighted a mortality rate of 2 % and a prevalence of renal sequelae at one year after D+HUS onset in 25 % of patients …

  • 0 views
  • 23 Jan, 2021
  • 1 location