Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 48 clinical trials
SCOPE: Observational Study of the Consequences of the Protease Inhibitor Era (SCOPE)

SCOPE is an observational, prospective study of HIV-1 infected volunteers designed to provide a specimen bank of samples with carefully characterized clinical data. SCOPE specimens will be used to examine multiple questions involving virologic, immunologic, and host factors involved in HIV-1 infection, progression, non-progression, response to treatment, control of HIV-1 …

antiretroviral
protease
hiv-1 infection
antiretroviral agents
antiretroviral therapy
  • 19 views
  • 04 Jun, 2022
  • 1 location
Adverse Events Related to Treatments Used Against Coronavirus Disease 2019 (CovidTox)

used molecules, including but not limited to protease inhibitors (lopinavir/ritonavir), chloroquine, azithromycin, remdesivir and interferon beta-1a. Analyses of reports also include the International

lopinavir/ritonavir
chloroquine
coronavirus
azithromycin
covid-19
  • 10 views
  • 02 Mar, 2022
  • 1 location
Assess Therapeutic Efficacy and Emergence of HIV Drug Resistance Following Initiation of TLD

medication that contains a boosted protease inhibitor (PI) drug (such as Lopinavir or Atazanavir) (Group 2). People taking TLD and receiving medication for TB that includes the drug rifampicin (RIF

  • 40 views
  • 10 Mar, 2022
  • 14 locations
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)

apolipoprotein of LDL, the apolipoprotein B (APOB), or the gene encoding a protease regulating LDLR levels on the cell membrane Lysosomal Acid Lipase A (LIPA) gene encode for Lysosomal acid lipase (LAL) enzyme

cholesterol esters
lipa gene
mixed hyperlipidemia
lipase
myocardial infarction
  • 3 views
  • 04 Oct, 2022
  • 4 locations
TURN-COVID Biobank: The Dutch Cohort Study for the Evaluation of the Use of Neutralizing Monoclonal Antibodies and Other Antiviral Agents Against SARS-CoV-2 (TURN-COVID)

Novel antiviral drugs can mark a turning point in the prevention and treatment of patients with Covid-19. Recently, several independent large phase-III RCTs have shown that the intravenous administration of one gift of neutralizing SARS-CoV-2 monoclonal antibodies can reduce the relative risk of hospital admission and/or death with 70-85% in …

  • 0 views
  • 21 Mar, 2022
  • 5 locations
Protease Activated Receptor-2 and Gastrointestinal Dysfunction in Critical Illness

associated with inflammation. There is evidence to suggest the protease-activated receptor 2 (PAR2) is a link between inflammation and GI dysfunction. PAR2 is a G-coupled receptor present throughout the GI

serine
zonulin
gi dysfunction
critical illness
  • 82 views
  • 05 Mar, 2021
  • 1 location
Contributing Factors for Poor HIV Treatment Response in Children With TB/HIV Coinfection

antituberculosis (anti-TB) therapy. This is because drug interactions between first-line anti-TB therapy with protease inhibitors (PIs) are more severe to adjust for, and interactions with integrase strand

rifampin
efavirenz
immunodeficiency
HIV Infection
antiretroviral agents
  • 1 views
  • 13 Apr, 2022
  • 1 location
Synovial Fluid Bank From Arthritic Patients

The objectives of this group project is to collect synovial fluid (SF) and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthritis, and to determine how therapeutic intervention regulate their …

  • 71 views
  • 23 Jan, 2022
  • 1 location
SLPI for Prostate Cancer

Exploratory study of SLPI expression in human prostate cancer patients This is a no-profit exploratory study about the expression of SLPI in human prostate cancer patients that will enroll about 200 patients admitted for suspect prostate cancer to Careggi University Hospital. We will verify whether an increase SLPI levels in …

  • 0 views
  • 25 May, 2022
  • 1 location
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers (Pre-COPD Pilot)

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco. The origin of this variability in susceptibility to develop COPD is unclear, but understanding its underlying biology has important implications for our ability to design suitable preventative and therapeutic strategies for …

chronic obstructive pulmonary disease
tobacco smoke
COPD
Accepts healthy volunteers
  • 0 views
  • 19 Jun, 2022
  • 1 location