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Found 48 clinical trials
Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study) (EPIC-HIV)

Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging which strongly predict future CV events in the general population. PCSK9 has emerged as an important pharmacologic target …

cholesterol level
fasting
type 2 diabetes mellitus
cholesterol measurement
hmg-coa reductase inhibitors
  • 17 views
  • 09 May, 2022
  • 1 location
STS Administration on Coronavirus Disease (COVID-19) Patients in Critical Care (H4COVID)

The primary purpose is to describe the safety of administration of three doses of STS to critically ill patients with confirmed COVID-19. A secondary purpose is to describe data on the clinical efficacy of administration of up to three doses of STS in critically ill patients with confirmed COVID-19.

covid-19
coronavirus
  • 0 views
  • 25 Apr, 2022
  • 1 location
Effects of Microbial Enzyme Supplementation on Postprandial Nutrient Levels and Gastrointestinal Symptoms in Healthy Middle-Aged and Older Adults (BIO-3003)

The primary objective of this study is to investigate the acute effects of a microbial multi-enzyme mixture ("BC-006") on postprandial nutrient levels in healthy, middle-aged to older adults during a mixed meal tolerance test. Additionally, the effects of twice daily consumption of BC-006 and placebo for 3 weeks on abdominal …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
HIV Pre-exposure Prophylaxis Implementation Study in South Korea

The primary objective of this study is to examine acceptability, patterns of use, rates of adherence, safety , and measured levels of drug when high risk men who have sex with men (MSM) are provided open-label tenofovir/emtricitabine (TDF/FTC) for PrEP in South Korea. Secondary objectives are 1) to evaluate HIV …

immune globulin
tenofovir
pre-exposure prophylaxis (prep)
HIV Vaccine
emtricitabine
  • 0 views
  • 26 Jan, 2021
A Phase 1b/2 Study of Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

Background Bronchiolitis obliterans syndrome (BOS) is a complication people can experience after hematopoietic stem cell transplant. It usually affects people with chronic graft versus host disease (cGVHD). This occurs when donor stem cells attack the cells of the person who received them. BOS reduces airflow and oxygen levels in the …

  • 37 views
  • 27 Oct, 2022
  • 1 location
The Effect of Donation Frequency on Donor Health in Blood Donors Donating Plasma by Plasmapheresis

This project is a randomized controlled non-inferiority study that aims to cover knowledge gaps about the composition and development of plasma proteins, inflammation markers and mental health in Norwegian, voluntary, and unpaid blood donors who donate plasma and blood. We will include 120 male blood donors who are randomized into …

Accepts healthy volunteers
  • 10 views
  • 13 Mar, 2022
  • 1 location
Effects of Edoxaban on Platelet Aggregation

Rationale: The interaction between nonvitamin K oral anticoagulants (NOACs) and platelet aggregation is complex. The direct activated factor X inhibitors (factor Xa inhibitors) an NOAC antagonizes thrombin generation, one of most important platelet agonist, so that, factor Xa inhibitors has a potential effect in decreasing thrombin-mediated platelet aggregation. On the …

coronary artery bypass graft
angiography
coronary angioplasty
anticoagulants
clopidogrel
  • 0 views
  • 22 Nov, 2021
  • 1 location
Epidemiologic, Clinical and Molecular Characteristics of Patients With Acute Respiratory Failure Affected by 2019-NCOV: A Retrospective-Prospective Cohort Study.

The main purpose of this study is to identify possible predictor factor of mortality in patients affected by COVID-19 with respiratory failure needing oxygen therapy or ventilatory support. In addiction the study aims to identify factors related to: predisposition to SARS-CoV2 viral infection, different symptoms, response to therapy, predisposition to …

  • 0 views
  • 23 Oct, 2022
  • 1 location
European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) SARS-CoV-2 Antibody Study Protocol (SARS-Cov2)

Scientific knowledge about the COVID-19 pandemic and the virus that is causing it (SARS-CoV-2) is developing rapidly, and the investigators have a clearer idea of the population groups who are at higher risk of becoming infected, having serious illness, and dying. However, less is known about COVID-19 in children, adolescents …

  • 0 views
  • 19 Oct, 2022
  • 5 locations
Long Term Follow up of Chronic HCV Patients Receiving DAAS

Follow up of Chronic hepatitis C Patients with moderate to severe fibrosis and cirrhosis treated with Direct Acting Antivirals after Sustained Virological Response for 4-5 years to detect changes in hepatic fibrosis and liver functions.

  • 0 views
  • 07 Jul, 2022
  • 1 location