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Found 45 clinical trials
68Ga-FAPI PET/CT in Malignant Tumors

Fibroblast-activation protein (FAP) is a type transmembrane serine protease and is overexpressed in cancer-associated fibroblasts (CAFs). CAFs are the predominant component in the stroma of

pet/ct scan
primary cancer
  • 0 views
  • 12 Sep, 2021
  • 1 location
Inducing Immune Quiescence the Genital Tract With ASA (IIQ-2)

activated T cells, increased levels of systemic T regulatory, increased production of anti-viral anti-protease serpins at the female genital tract and reduced numbers of HIV target cells (mainly CD4+ CCR5

protease
AIDS
Accepts healthy volunteers
HIV Vaccine
  • 0 views
  • 22 Mar, 2022
  • 1 location
Immunity and Safety of Covid-19 Synthetic Minigene Vaccine

synthetic minigene has been engineered based on conserved domains of the viral structural proteins and a polyprotein protease. The infection of Covid-19 is mediated through binding of the Spike protein to

  • 821 views
  • 27 Feb, 2022
  • 3 locations
Safety and Immunity of Covid-19 aAPC Vaccine

immunogenic targets, a synthetic minigene has been engineered based on conserved domains of the viral structural proteins and a polyprotein protease. The infection of Covid-19 is mediated through binding of

  • 183 views
  • 01 Mar, 2022
  • 1 location
Pleiotropic Role of TRPV1 in Psoriasis Inflammation

is mediated by the protease-activated receptor-2 (PAR-2). However, the role of vascular TRPV1 in inflammation is not described. The investigators hypothesize that in addition to neuronal

vascular inflammation
  • 0 views
  • 08 Jan, 2022
  • 1 location
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression

This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2. The main goals of this study are to: Find the recommended dose of BT5528 that can be given safely to participants alone and …

breast ductal carcinoma
breast cancer
nivolumab
lung carcinoma
solid tumour
  • 20 views
  • 04 Oct, 2022
  • 21 locations
A Study to Assess the Acceptability of the Darunavir/Cobicistat (DRV/COBI) Fixed-dose Combination (FDC) Tablet in Human Immunodeficiency Virus (HIV)-1 Infected Children

The purpose of the study is to assess the ability to swallow the Darunavir/Cobicistat (DRV/COBI) fixed dosed combination (FDC) tablet dispersed in water.

darunavir
immunodeficiency
cobicistat
  • 0 views
  • 07 Oct, 2022
  • 3 locations
Clinical Investigation of Safety and Performance of a Medical Device (ClearPlasma) for the Treatment of Patients With Acute Upper Gastrointestinal Hemorrhage.

Pre-market, multi-center, international, double-blind, randomized, controlled, prospective, first-in-human clinical investigation of a Class IIb Investigational Medical Device, in which Patients presenting with acute upper gastrointestinal hemorrhage (AUGIH) and due to undergo a plasma transfusion, will be randomized to receive a one-time infusion (up to 8 hours) of up to two …

  • 0 views
  • 02 May, 2022
  • 7 locations
Strategic Treatment Reduction in Very Early Liver Disease With 4 Weeks Sofosbuvir Plus Glecepravir-pibrentasvir (STRIVE-4)

This study aims to evaluate the efficacy, safety and feasibility of four weeks of sofosbuvir plus glecaprevir-pibrentasvir, followed by immediate retreatment of virological relapse with glecepravir-pibrentasvir for 12 weeks, in treatment-naïve participants with chronic HCV infection and early liver disease (F0-F2).

  • 0 views
  • 27 Apr, 2022
  • 3 locations
Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study) (EPIC-HIV)

Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging which strongly predict future CV events in the general population. PCSK9 has emerged as an important pharmacologic target …

cholesterol level
hiv-1 rna measurement
dyslipidemia
stroke
coronary heart diseases
  • 17 views
  • 09 May, 2022
  • 1 location