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Found 79 clinical trials
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CAMOVID : Evaluation of Efficacy and Safety of Camostat Mesylate for the Treatment of SARS-CoV-2 Infection - COVID-19 in Ambulatory Adult Patients

with risk factors of severe COVID-19. Camostat mesylate is a serine protease TMPRSS2 (Transmembrane Serine Protease 2) inhibitor which has been successfully and safely used to treat pancreatitis

  • 0 views
  • 14 Apr, 2021
  • 5 locations
None
Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients

protease inhibitors, in order to determine the extent of any cellular radiosensitizing properties of these molecules; - To develop strategies for sensitizing tumour cells to radiation

cervical carcinoma
radiosensitizer
cancer
chemotherapeutic agent
  • 197 views
  • 07 Nov, 2020
  • 3 locations
None
Human and Bacterial Protease Activity as Prognostic Tool of Foot Infections in Diabetic Patients

This study will establish whether human and bacterial protease activity can aid therapeutic decision-making, including targeted treatments.

  • 0 views
  • 16 Aug, 2021
  • 4 locations
None
PI Vs. NNRTI Based Therapy for HIV Advanced Disease

Ritonavir boosted protease inhibitor based therapy will have equivalent antiviral efficacy over 48 weeks compared to NNRTI based therapy in patients who are antiretroviral therapy naïve

zidovudine
lamivudine
protease
antiviral
antiretroviral agents
  • 42 views
  • 07 Nov, 2020
  • 5 locations
None
Study of PBI-0451 in Healthy Subjects.

This is a phase 1, placebo-controlled, blinded, randomized, dose escalation study of PBI-0451 in healthy subjects. PBI-0451 is a new chemical entity and inhibitor of the main protease of

Accepts healthy volunteers
  • 46 views
  • 22 Oct, 2021
  • 1 location
None
The Potential of Oral Camostat in Early COVID-19 Disease in an Ambulatory Setting to Reduce Viral Load and Disease Burden

study is to assess whether Camostat, a serine protease inhibitor available in an oral formulation has the potential to be studied as an antiviral drug in a large scale ambulatory setting to prevent

  • 0 views
  • 02 Sep, 2021
  • 1 location
None
Efficacy of Nafamostat in Covid-19 Patients (RACONA Study)

RACONA is a prospective trial that will test the hypothesis that nafamostat can lower lung function deterioration and need for intensive care admission in COVID-19 patients. Design: Adult hospitalized COVID-19 patients will be randomized in a prospective double-blind randomized placebo-controlled study to test the clinical efficacy of nafamostat mesylate (administered …

  • 0 views
  • 19 Jun, 2021
  • 1 location
None
Pilot Study of Raltegravir Lipodystrophy IISP

The substitution of raltegravir for the NRTIs will result in some reversal of the long term adverse effect of lipodystrophy (specifically peripheral lipoatrophy) that is associated with the chronic use of NRTIs. Changing the HAART regimen in patients with a sustained virological response from a PI plus NRTI to a …

raltegravir
haart
lipodystrophy
  • 34 views
  • 08 Nov, 2020
  • 1 location
None
An Open-Label Study of Apabetalone in Covid Infection

The primary objective of the study is to evaluate the safety and effect on clinical course of oral apabetalone in hospitalized subjects with Covid-19 infection

  • 0 views
  • 09 Nov, 2021
  • 1 location
None
Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults

The purpose of this study is to test the efficacy of an oral, nutrient intervention containing the bioactive components of fish oil to promote healing of chronic venous leg ulcers (CVLUs) by reducing the chronic inflammation at wound sites that prevents healing progression. If this systemic, nutrient intervention is found …

  • 2 views
  • 16 Mar, 2021
  • 1 location