Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 25 clinical trials
None
Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Combination therapy in pulmonary arterial hypertension (PAH) has been the subject of active investigation for more than a decade, with the benefit of targeting different pathways known to be involved in the pathogenesis of the disease. Adherence to prescribed therapy has an impact on clinical outcomes. Reducing the pill/tablet count …

  • 124 views
  • 02 Dec, 2021
  • 226 locations
None
Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI

include a free-breathing ultra-short echo time scan that provides images similar to that of a CT scan. This will be done pre, immediately post, and 2-4 hours post inhaled prostacyclin therapy.

  • 0 views
  • 08 Jul, 2021
  • 1 location
None
Platelet Gel in Systemic Sclerosis

, infection and osteomyelitis. - Although the availability of drugs as i.v. prostacyclin analogs, oral vasodilating agents, oral phosphodiesterase-5 inhibitors, oral endothelin receptor

fibrosis
transforming growth factor beta-1
vasodilator
prostanoids
endothelin
  • 24 views
  • 07 Nov, 2020
  • 1 location
None
Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial Hypertension

Under placebo control, the investigators intend to evaluate the effectiveness and safety of anti-inflammatory therapy and/or targeted drug therapy for early treatment of patients with pulmonary arterial hypertension.

hypertension
ambrisentan
diuretics
digoxin
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment

A single centre, placebo controlled, blinded (participant, investigator, outcome assessor) trial to evaluate the effects of COX-2 inhibition with celecoxib on endothelial function in healthy male volunteers.

  • 0 views
  • 07 Sep, 2021
  • 1 location
None
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with Pulmonary Arterial Hypertension (PAH) in comparison to placebo.

primary pulmonary hypertension
endothelin receptor antagonist
pulmonary arterial hypertension
right heart catheterization
endothelin
  • 201 views
  • 02 Dec, 2021
  • 159 locations
None
A Study in Participants With Sarcoidosis-associated Pulmonary Hypertension (SAPH) to Assess the Efficacy and Safety of Oral Selexipag

Oral selexipag is commercially available in several countries for the treatment of a particular group of pulmonary hypertension (PH) called pulmonary arterial hypertension (PAH). The aim of the present study is to investigate whether selexipag could be helpful to treat patients with another form of PH called sarcoidosis-associated pulmonary hypertension …

  • 0 views
  • 03 Dec, 2021
  • 77 locations
None
A Long-term Follow-up Study of Sotatercept for PAH Treatment

This study is being conducted to assess the long-term safety, tolerability, and efficacy of sotatercept in PAH.

  • 0 views
  • 28 Oct, 2021
  • 18 locations
None
Prostacyclin (PGI2) Pathway to Enhance Wound Healing in Diabetic Foot Ulcers

Prospective, monocentric, pathophysiological study, comparing 3 parallel groups: healthy controls; patients with diabetes and without DFU; patients with diabetes and with DFU. To address secondary objectives, samples from a fourth group will be collected.

Accepts healthy volunteers
diabetes
foot ulcer
neuropathy
skin ulcers
  • 0 views
  • 06 Nov, 2021
  • 1 location
None
Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure

The purpose of this trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in up to a total of 380 patients with septic shock suffering from organ failure. The study hypothesis is that iloprost may be beneficial as an …

sepsis
lactic acid
organ failure
lactate level
vasoconstrictor
  • 1 views
  • 03 Dec, 2021
  • 8 locations