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Found 30 clinical trials
Perioperative Intervention to Reduce Metastatic Processes in Pancreatic Cancer Patients Undergoing Curative Surgery (BC-PC)

-metastatic immune functions. Congruently, our animal studies indicate that combined use of the beta-adrenergic blocker, propranolol, and the prostaglandins inhibitor, etodolac - but neither drug separately

metastasis
adenocarcinoma
  • 9 views
  • 18 Feb, 2022
  • 2 locations
Metronomic Treatment in Children and Adolescents With Recurrent or Progressive High Risk Neuroblastoma (METRO-NB2012)

to be low due to the low (but continuous) dosing of drugs. The study investigates the tolerance and the efficacy of a new combination of five drugs consisting of propranolol (antiangiogenetic

iobenguane
bone marrow procedure
cancer
platelet count
high-risk neuroblastoma
  • 17 views
  • 25 Feb, 2022
  • 8 locations
Extension Study of Carvedilol RCT Study

Patients who have completed 2-years treatment in RCT Study of carvedilol will receive another 2-years extension therapy, aiming to investigate the long-term efficacy of carvedilol for the prevention of esophageal varices in treated HBV cirrhotic patients.

carvedilol
esophageal varices
  • 0 views
  • 01 Sep, 2021
  • 14 locations
Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding

Study hypothesis: Hepatic venous pressure gradient (HVPG)-directed primary prophylaxis with nonselective beta-blocker therapy (NSBB) leads to a reduction in first variceal bleeding episodes and is cost-effective in the long term. Study design: A multi-center randomized controlled study comparing nonselective beta-blocker therapy guided by the hemodynamic response as determined by the …

propranolol
beta blockers
cirrhosis
carcinoma
esophageal varices
  • 15 views
  • 23 Jan, 2021
  • 5 locations
DNA Vaccination Against Neuroblastoma

This is pilot open-label study to evaluate the safety and immunogenicity of a DNA vaccine strategy in relapsed neuroblastoma patients following chemotherapy and HSC transplantation. The combined form of the vaccine includes an intramuscular injection of the DNA-polyethylenimine conjugate and oral administration using the attenuated Salmonella enterica as DNA vaccine …

bone marrow procedure
lenalidomide
  • 8 views
  • 13 Mar, 2022
  • 1 location
Exercise Training and Fat Metabolism in Postmenopausal Women

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of …

hemoglobin a1c
diabetes
fasting
fasting blood glucose
oral glucose tolerance test
  • 0 views
  • 04 Oct, 2022
  • 1 location
Timing of Endoscopic Intervention for Acute Variceal Hemorrhage: an RCT

Acute variceal upper gastrointestinal bleeding remains a hot potato in cirrhotic patients. The purpose of this study is to figure out whether urgent endoscopy (within 6h after gastroenterological consultation) is superior to non-urgent endoscopy (between 6h and 24h after gastroenterological consultation) in reducing re-bleeding for these patients. This is a …

  • 0 views
  • 13 May, 2021
  • 1 location
POTS Adrenergic Ab (CIHR Aims #1&2)

Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.

isoproterenol
Accepts healthy volunteers
  • 27 views
  • 24 Mar, 2022
  • 1 location
Population Pharmacokinetics of Propafenone and Propranolol in Children Patients

The use of propafenone and propranolol in children during clinical treatment was depending mostly on experience. Besides, there was no recommended dose for children in drug instruction

propafenone
  • 0 views
  • 04 Oct, 2022
  • 1 location
CandeSpartan Study. Candesartan Spanish Response-prediction and Tolerability Study (CandeSpartan)

Observational, prospective, descriptive, open study on response predictors and tolerability of Candesartan in patients >18 years with episodic or chronic migraine with prior failure of three or more preventive drugs. Patients will receive Candesartan the same manner and intensity if they were not enrolled in the study. Vital signs, clinical …

migraine
headache disorder
headache
headache occurring
chronic migraine
  • 2 views
  • 26 Mar, 2022
  • 1 location