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Found 57 clinical trials
Multicenter Study of Blood Biomarkers of Mitochondrial and Peroxisomal Metabolism to Differentiate Idiopathic Parkinson's Disease From Related Conditions (BiomarPark)

Parkinson's disease (IPD) from atypical Parkinsonian syndromes (AP), which include multiple system atrophy (MSA), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), for which the

parkinsonism
  • 0 views
  • 25 Jan, 2022
  • 1 location
Oxford Study of Quantification in Parkinsonism (OxQUIP)

The OxQUIP (Oxford QUantification In Parkinsonism) study is recruiting patients with Parkinson's Disease and Progressive Supranuclear Palsy. Currently available treatments for these diseases are

parkinsonism
progressive supranuclear palsy
Accepts healthy volunteers
neurological disorder
parkinson's disease
  • 1 views
  • 26 Jan, 2022
  • 1 location
Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL)

To perform a prospective cohort study with FEOBV brain PET at baseline and 2-year follow-up in PD subjects at risk of conversion to non-episodic and episodic (falls and FoG) PIGD motor features and cognitive changes at the same time points.

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Quantitative Diagnostics of Parkinsonian Syndromes Using Multi-modal Neuroimaging and Deep Learning

The goals of this study are: 1) to identify biomarkers using neuroimaging that are associated with progression rate using statistical methods, and 2) to identify biomarkers that are associated with the differential diagnosis of Parkinson's disease and atypical parkinsonism.

orthostatic hypotension
supranuclear palsy
Accepts healthy volunteers
atrophy
parkinsonism
  • 155 views
  • 18 Oct, 2022
  • 1 location
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Background Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells. Researchers want to understand whether these diseases have related causes or risk factors. Objective To test people with movement or thinking and memory problems to see if they …

abnormal protein
frontotemporal lobar degeneration
blood tests
progressive bulbar palsy
aphasia
  • 61 views
  • 04 Oct, 2022
  • 1 location
The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech (SLD4T)

The purpose of this study is to identify and distinguish two different types of Progressive Apraxia of Speech through clinical imaging and testing.

cognitive assessment
  • 72 views
  • 19 Apr, 2022
  • 1 location
CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of dementia and currently has no disease modifying treatments or simple accurate diagnostic tests. The goal of this project is to study how tau (a protein thought to cause AD) is made, transported and cleared in the human body. Better understanding of …

l-leucine
dementia
alzheimer's disease
Accepts healthy volunteers
neurological disorder
  • 92 views
  • 03 May, 2022
  • 1 location