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Found 43 clinical trials
Trial of Parkinson's And Zoledronic Acid (TOPAZ)

This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will …

vascular parkinsonism
parkinsonism
zoledronic acid
screening procedures
parkinson's disease
  • 256 views
  • 12 May, 2022
  • 53 locations
The Swedish BioFINDER 2 Study (BioFINDER2)

The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g. to characterize the role of beta-amyloid pathology in early diagnosis of Alzheimer's disease (AD) using amyloid-PET (18F-Flutemetamol) and A analysis in …

major neurocognitive disorder
early diagnosis
mild cognitive impairment
mini-mental state examination
brain imaging
  • 178 views
  • 25 Feb, 2022
  • 1 location
Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy

The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP by increasing functional connectivity between the …

dopamine
screening procedures
  • 42 views
  • 30 May, 2022
  • 1 location
Efficacy and Safety of Transcranial dIrect Current stiMulation (tDCS) in Progressive Supranuclear Palsy (PSP) (STIM-PSP) (STIM-PSP)

symptoms in Progressive Supranuclear Palsy (PSP) over the left dorsolateral prefrontal cortex (dlPFC).

movement disorder
  • 0 views
  • 23 Mar, 2022
  • 1 location
Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP)

Prior research has identified profound sleep disruption in individuals with PSP. Not only were these individuals sleeping relatively short periods at night, they were also not recuperating lost sleep during the day. Research also showed the relative preservation of a series of nuclei key in regulating wake and arousal. Investigators …

  • 24 views
  • 10 May, 2022
  • 1 location
The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy

supranuclear palsy patients after the SCS surgery to evaluate safety. Meanwhile, improvement in gait disorder (including 10MWT and TUG test score) will be measured to evaluate efficacy.

parkinson's disease
movement disorder
  • 12 views
  • 09 Apr, 2022
  • 1 location
Evaluation of [18F]APN-1607 as a PET Biomarker

The overall goal of this protocol is to evaluate [18F]APN-1607 as a PET radiotracer for measuring longitudinal change in tau pathology in participants with PSP.

stroke
datscan
Accepts healthy volunteers
mini-mental state examination
brain mri
  • 0 views
  • 26 Jan, 2022
  • 1 location
Mobility in Atypical Parkinsonism: a Trial of Physiotherapy (Mobility_APP)

Patients with atypical parkinsonism often show gait and mobility impairment manifesting in early disease stages. In order to maintain mobility and physical autonomy as long as possible for these patients, we will examine the effect of two types of physiotherapy in patients with multiple system atrophy (MSA), progressive supranuclear gaze …

parkinson's disease
parkinsonism
antiparkinsonian agents
atrophy
gaze palsy
  • 0 views
  • 26 Jan, 2022
  • 1 location
Evaluation of Imaging Characteristics of [18F]PI-2620 PET in AD and PSP Patients Using High and Low Specific Activity

This is an open-label study without randomisation. All eligible patients will receive two administrations of the investigational imaging agent [18F]PI-2620 at a radioactive dose of 185 MBq, one with high specific activity ( 5 g tracer mass dose), another one with low specific activity (40-50 g tracer mass dose).

senile plaques
mini-mental state examination
cognitive assessment
amyloid
movement disorder
  • 0 views
  • 26 Jan, 2022
  • 1 location
Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients (EMST-PS)

This is an interventional therapy study designed to evaluate the efficacy of a two-week intervention, i.e. training with a specialized exhalation training device (called expiratory muscle strength training; EMST150 or EMST75; Aspire Products, Gainsville, FL) on swallowing function in patients with neurodegenerative Parkinsonian disorders. This study involves a routine endoscopic …

parkinson's disease
atrophy
gaze palsy
  • 0 views
  • 19 Apr, 2022
  • 2 locations