Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 82 clinical trials
A Pre-operative Window Study of Letrozole Plus PR Agonist (Megestrol Acetate) Versus Letrozole Alone in Post-menopausal Patients With ER-positive Breast Cancer

with a good clinical outcomes. This highlights a potential therapeutic opportunity. The PIONEER trial will investigate the effect of combining megestrol acetate (a progesterone receptor agonist

advanced breast cancer
letrozole
carcinoma
estrogen receptor
progesterone receptor
  • 3 views
  • 28 Jan, 2021
  • 1 location
Pembrolizumab With Carboplatin Compared to Carboplatin Alone in Breast Cancer Patients With Chest Wall Disease

This is a phase II multicenter study including breast cancer patients with chest wall disease that is hormone resistant (estrogen receptor (ER) positive/progesterone receptor (PR) positive/human

advanced breast cancer
carcinoma
progesterone receptor
EGFR
estrogen receptor
  • 3 views
  • 03 Jun, 2021
  • 11 locations
Olaparib With or Without Atezolizumab in Treating Patients With Locally Advanced Unresectable or Metastatic Non-HER2-Positive Breast Cancer

This randomized phase II trial studies how well olaparib with or without atezolizumab work in treating patients with non-HER2-positive breast cancer that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection (locally advanced unresectable) or has spread to …

serum pregnancy test
international normalized ratio
neutrophil count
liver metastasis
bisphosphonate
  • 281 views
  • 21 Jul, 2021
  • 42 locations
Pembrolizumab and Binimetinib in Treating Patients With Locally Advanced or Metastatic Triple Negative Breast Cancer

This phase I/II trial studies the best dose of pembrolizumab and binimetinib and how well it works when given together with pembrolizumab in treating patients with triple negative breast cancer that has spread to other parts of the body (metastatic). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the …

platelet count
serum pregnancy test
progesterone receptor
estrogen receptor
neutrophil count
  • 16 views
  • 22 Jun, 2021
  • 3 locations
Women's MoonShot: Neoadjuvant Treatment With PaCT for Patients With Locally Advanced TNBC

This phase II trial studies how well panitumumab, carboplatin and paclitaxel work in treating patients with newly diagnosed triple negative breast cancer that is limited to the breast and possibly to the nearby lymph nodes (locally advanced). This treatment study is linked to NCI-2015-00191 protocol, which uses a baseline biopsy …

EGFR
progesterone receptor
estrogen receptor
neutrophil count
estrogen
  • 0 views
  • 24 Apr, 2021
  • 2 locations
Enzalutamide and Paclitaxel Before Surgery in Treating Patients With Stage I-III Androgen Receptor-Positive Triple-Negative Breast Cancer

This phase IIB trial studies how well enzalutamide and paclitaxel before surgery works in treating patients with stage I-III androgen receptor-positive triple-negative breast cancer. Androgens can cause the growth of triple-negative breast cancer. Anti-hormone therapy, such as enzalutamide, prevent androgen from binding to the androgen receptor, thereby decreasing cell growth …

carcinoma
therapeutic conventional surgery
progesterone receptor
neutrophil count
EGFR
  • 0 views
  • 21 Mar, 2021
  • 2 locations
Eliminating Surgery After Systemic Therapy in Treating Patients With HER2 Positive or Triple Negative Breast Cancer

This clinical trial studies eliminating surgery and how well radiation therapy after systemic therapy works in treating patients with HER2 positive or triple negative breast cancer when image-guided biopsy shows no residual cancer. Patients then receive standard breast radiotherapy.

triple negative breast cancer
cancer
metastasis
estrogen receptor
biomarker analysis
  • 29 views
  • 21 Jul, 2021
  • 9 locations
Multi-epitope Folate Receptor Alpha Peptide Vaccine GM-CSF and Cyclophosphamide in Treating Patients With Triple Negative Breast Cancer

This randomized phase II trial studies how well multi-epitope folate receptor alpha peptide vaccine, sargramostim (GM-CSF), and cyclophosphamide work to prevent the recurrence of stage 1-3 triple negative breast cancer. Vaccines made from a person's white blood cells mixed with tumor proteins may help the body build an effective immune …

platelet count
serum pregnancy test
carcinoma
progesterone receptor
estrogen receptor
  • 23 views
  • 09 Jul, 2021
  • 14 locations
Pegylated Liposomal Doxorubicin Hydrochloride and Carboplatin Followed by Surgery and Paclitaxel in Treating Patients With Triple Negative Stage II-III Breast Cancer

This phase II trial studies how well pegylated liposomal doxorubicin hydrochloride and carboplatin followed by surgery and paclitaxel work in treating patients with stage II-III breast cancer that does not have estrogen receptors, progesterone receptors, or large amounts of human epidermal growth factor receptor 2 (HER2)/neu protein (triple negative). Drugs …

therapeutic conventional surgery
human chorionic gonadotropin
neutrophil count
progesterone receptor
bone scan
  • 1 views
  • 25 Jan, 2021
  • 1 location
A Study of VLS-101 in Patients With Solid Tumors

This is a Phase 2 study evaluating the efficacy, safety, pharmacokinetics, immunogenicity, and pharmacodynamics of VLS-101 in patients with metastatic solid tumors. VLS-101 is an antibody- drug conjugate (ADC) that targets receptor tyrosine kinase-like orphan receptor 1 (ROR1) on cancer cells.

  • 0 views
  • 11 Apr, 2021
  • 3 locations