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Found 53 clinical trials
Onapristone and Anastrozole for the Treatment of Refractory Hormone Receptor Positive Endometrial Cancer

This phase II trial studies the effect of onapristone and anastrozole in treating patients with hormone receptor positive endometrial cancer that has not responded to previous treatment (refractory). Progesterone and estrogen are hormones that can cause the growth of endometrial cancer cells. Onapristone blocks the use of progesterone by the …

serous adenocarcinoma
metastasis
cancer
carcinoma
estrogen
  • 5 views
  • 04 Oct, 2022
  • 2 locations
The LYSA (Linking You to Support and Advice) Trial (LYSA)

This study's aim is to evaluate the feasibility of introducing a women's malignancy survivorship clinic incorporating symptom management through ePRO collection (complex intervention) into routine follow up care in patients with early-stage Hormone Receptor(HR)-positive breast and gynaecologic cancer post primary curative therapy.

erbb2
endocrine therapy
immunomodulator
HER2
adjuvant chemotherapy
  • 2 views
  • 16 Jun, 2022
  • 1 location
Single-arm, Multi-center Clinical Study of Pyrotinib Maleate Tablets Combined With Albumin-bound Paclitaxel and Trastuzumab in Neoadjuvant Treatment of Her2-positive Early or Locally Advanced Breast Cancer

This study aimed to evaluate the Pyrotinib in combination with albumin-bound paclitaxel and trastuzumab to neoadjuvant therapy efficacy and safety of Her2-positive early or locally advanced breast cancer

erbb2
paclitaxel
locally advanced breast cancer
HER2
immunohistochemistry
  • 0 views
  • 28 Oct, 2022
  • 1 location
Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens

Women at risk for development of breast cancer and experiencing vasomotor menopausal symptoms (hot flashes) will be randomized to bazedoxifene (BZA) plus conjugated estrogens (CE) for 6 months versus a wait list control. Two risk factors for development of breast cancer will be studied pre-study and after 6 months: fibroglandular …

estrogen
Accepts healthy volunteers
mammogram
ki-67
  • 0 views
  • 21 Mar, 2022
  • 1 location
Alcohol and Breast Cancer (ABC) Trial

This research study is a pilot study, which is the first time investigators are examining the effect of light alcohol consumption on sex hormones among postmenopausal women with estrogen receptor-positive (ER+) breast cancer taking an aromatase inhibitor The names of the study exposures involved in this study are: White wine …

letrozole
arimidex
exemestane
anastrozole
estrogen
  • 0 views
  • 07 Oct, 2022
  • 1 location
The Trial Comparing Dose-dense AC-T With TP as Adjuvant Therapy for TNBC With Homologous Recombination Repair Deficiency

The purpose of this trial is to compare the 3-year disease-free survival of dose-dense epirubicin and cyclophosphamide followed by paclitaxel with paclitaxel plus carboplatin as adjuvant therapy for triple-negative breast cancer with homologous recombination repair deficiency. The other purpose of this trial is to observe the patient's tolerance.

  • 0 views
  • 22 Jan, 2021
  • 1 location
Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer

This phase II trial studies the effect of megestrol acetate alone or in combination with metformin in preventing the progression of uterine pre-cancer (endometrial intraepithelial neoplasia) to endometrial cancer. Megestrol acetate is a drug used to block estrogen and suppress the effects of estrogen and androgens. It is the current …

uterine disease
cancer
a hemoglobin
megestrol
estrogen
  • 0 views
  • 15 Jul, 2022
  • 5 locations
Natural Progesterone for the Treatment of Recurrent Glioblastoma

This early phase I trial identifies the best dose, possible benefits and/or side effects of natural progesterone in treating patients with glioblastoma that has come back (recurrent). Progesterone is a type of hormone made by the body that plays a role in the menstrual cycle and pregnancy. Progesterone may help …

karnofsky performance status
recurrent glioblastoma
platelet count
gliosarcoma
neutrophil count
  • 0 views
  • 30 Apr, 2022
  • 1 location
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy

The purpose of this study is to evaluate the safety and efficacy of dutasteride in reducing drinking and heavy drinking in men and women with alcohol use disorder. The investigators hypothesize that dutasteride 1 mg per day will be well tolerated in this patient population and that, compared to placebo …

heavy drinking
dutasteride
  • 26 views
  • 27 Jun, 2022
  • 1 location
The PROMISE Study: Duavee in Women With DCIS

The main purpose of this study is to determine if taking the study drug, conjugated estrogens/bazedoxifene (Duavee) causes any changes in the proliferation markers within the breast tissue of the study subjects. The study drug is approved by the US Food and Drug Administration in healthy postmenopausal women to treat …

biomarker analysis
progesterone
breast cancer
cancer
estrogen
  • 264 views
  • 26 Jan, 2022
  • 10 locations