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Found 10 clinical trials
Anal Dilatation Plus Probiotics Before Ileostomy Reduction for Low Anterior Resection Syndrome (PILLARS)

This is randomized, phase 2 trial in patients with rectal cancer undergoing sphincter-preserving proctectomy and temporary ileostomy, to explore the effects of anal dilatation plus probiotics

  • 0 views
  • 23 Mar, 2022
  • 1 location
Fibroblast Before and After Neoadjuvant Chemo-radiotherapy in Patient With Locally Advanced Rectal Adenocarcinoma (FibroRect)

Single center interventional study to explore activity of fibroblasts in the tumor and away in the healthy rectal tissue.

  • 2 views
  • 21 Apr, 2022
  • 3 locations
Evaluate Efficacy, Morbidity and Functional Outcome of Endoscopic TranAnal Proctectomy vs Standard Transabdominal Laparoscopic Proctectomy for Rectal Cancer (ETAP)

comparable oncological results. However, the risk of conversion to open procedure remains significant. Endoscopic Transanal Proctectomy allows retrograd mesorectal excision, performing the whole

coloanal anastomosis
open surgery
proctectomy
adenocarcinoma of rectum
adenocarcinoma
  • 1 views
  • 24 Feb, 2022
  • 1 location
Impact of a Patient-Centered Program for Low Anterior Resection Syndrome A Multicenter Randomized Controlled Trial

After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS). Increased LARS severity

rectal carcinoma
low anterior resection
cancer
proctectomy
  • 0 views
  • 04 Oct, 2022
  • 5 locations
A Phase II Study of Sacral Nerve Stimulation for Low Anterior Resection Syndrome or Fecal Incontinence in Patients Following a Low Anterior Resection or Proctectomy With Coloanal Anastomosis or in Patients After Pelvic Chemoradiation (RESTORE)

This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to nearby tissues or lymph nodes, or other pelvic cancer. Sacral nerve stimulation is a …

conventional surgery
explantation
sacral nerve stimulation
adenocarcinoma
primary cancer
  • 0 views
  • 20 Sep, 2022
  • 2 locations
Early Ileostomy Closure for Rectal Cancer Patients in North America

proctectomy (RP) and diverting loop ileostomy (DLI). The feedback from leaders in Europe further supports the need for a large scale randomized-controlled trial (RCT) on this subject in North America. Should

proctectomy
total mesorectal excision
  • 0 views
  • 04 Oct, 2022
  • 4 locations
Development of a Clinical and Biological Database in Rectum Cancer (BCBRectum)

A Clinical and Biological Database will provide to the scientific community a collection of blood and tissues with clinical data to improve knowledge about cancer and help to develope new cancer treatments. This database is specific to Rectum Cancer.

cancer
rectal carcinoma
  • 0 views
  • 11 Feb, 2022
  • 1 location
Interactive Online Informational and Peer Support App for Patients With Low Anterior Resection Syndrome

After surgery for rectal cancer, many people undergo changes in bowel habits, which may include the need to empty their bowels more often, accidental leakage of stool or gas, the sudden urge to go to the bathroom, and more. The term "Low Anterior Resection Syndrome" or LARS is used to …

  • 0 views
  • 04 Oct, 2022
  • 5 locations
Study of Mesenchymal Stem Cells for Pediatric Perianal Fistulizing Crohn's Disease

This study plans to enroll 10 patients aged 13-17 years of age with refractory perianal fistulizing disease. Patients will be treated by direct injection to the fistula tract(s) with 75 million allogeneic bone marrow derived mesenchymal stem cells at baseline and again after 3 months if not completely healed.

  • 0 views
  • 18 Apr, 2022
  • 1 location
Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer (NO-CUT)

NO-CUT is a one-stage phase II trial seeking to establish whether an oxaliplatin-based chemotherapy preceding standard neo-adjuvant fluoropyrimidines-based chemo radiotherapy, can safely spare demolitive surgical intervention in patients with operable rectal cancer, without increasing the risk of distant relapse. The trial also has a translational component aimed at establishing whether …

adenocarcinoma
neutrophil count
metastasis
oxaliplatin
fluoropyrimidine
  • 1 views
  • 04 Mar, 2022
  • 1 location