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Found 59 clinical trials
PROcalcitonin Impact on Antibiotic Reduction adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT

Trials comparing PCT-guided antibiotic algorithms to standard management show a significant reduction in antibiotic exposure without an increase in mortality or treatment failure. Despite this strong evidence from multiple studies a recent prospective multicentric interventional trial in the US fell short of demonstrating antibiotic reductions by PCT-guided antibiotic management. Amongst …

procalcitonin
antibiotic therapy
community acquired pneumonia
antibiotics
  • 0 views
  • 26 Jan, 2021
  • 2 locations
Impact of a PCT(Procalcitonin) Rapid Test -Based Approach on ATB (Antibiotics) Use in Children With Fever Without Source

decreasing the length of stay in the ED, the investigators hypothesize that integrating this new capillary Procalcitonin (PCT) rapid test in the DIAFEVER CPR (Clinical Prediction Rules) could represent a

  • 14 views
  • 25 Jan, 2021
  • 28 locations
A Procalcitonin-based Algorithm in Adhesion-related Small Bowel Obstruction

difficult due to the absence of specific signs. The objective of this study is to evaluate the clinical impact of a procalcitonin-based algorithm.

  • 0 views
  • 29 Jul, 2021
  • 1 location
Evaluation of the Roche Cobas Liat Flu/Respiratory Syncytial Virus (RSV) Assay for Management of Influenza in the Emergency Department

This will be a prospective, patient-oriented, pilot randomized clinical trial to evaluate (in aggregate) both the use of the Roche Cobas Liat Flu/RSV Assay and the use of pharmacist-led education for providers in the interpretation of these test results.

cough
flu symptoms
fever
respiratory tract infection
sore throat
  • 58 views
  • 10 May, 2021
  • 1 location
Etiologic Mechanisms Myocardial Changes and Prognosis of Patients With MINOCA

This prospective trial will include 150 patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). A thorough clinical, laboratory and imaging evaluation will be performed by novel biomarkers and modern imaging techniques (heart magnetic resonance imaging and noninvasive testing). Moreover, two different treatment groups will be distinguished. Additionally, a retrospective …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Clinical Experimentation With Tenofovir Disoproxyl Fumarate and Emtricitabine for COVID-19

Clinical, control, double-blind, randomized trial with tenofovir disoproxyl fumarate and emtricitabine for Covid-19

  • 0 views
  • 01 Feb, 2021
  • 1 location
Baricitinib in Hospitalized Covid-19 Patients With Diabetes Mellitus

To date, some of the most promising drugs used in the treatment of COVID pneumonia are systemic corticosteroids, remdesivir and baricitinib. Dexamethasone has been found efficacious in reducing mortality in patients requiring supplemental oxygen and mechanical ventilation. There is a trend towards reduced mortality in patients who receive remdesivir and …

  • 0 views
  • 01 Aug, 2021
  • 8 locations
PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis

The investigators' objective is to compare the risk of mortality and/or treatment failure in children admitted to the PICU with sepsis and managed by PCT guided therapy for stopping of antibiotics ('study' group) with those managed with 'standard practices' based on the evidence based guidelines ('control' group). Children with suspected …

sepsis
inflammatory response
antibiotic therapy
systemic inflammatory response syndrome
antibiotics
  • 0 views
  • 19 Jul, 2021
  • 1 location
Accelerated Treatment of Endocarditis

from patients (echo, temperature, CRP, leukocytes, procalcitonin etc.) to determine duration of treatment. A strategy including these data in treatment algorithms ensures an individualized treatment

  • 0 views
  • 23 Jan, 2021
  • 8 locations
Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients With Sepsis

Studies have demonstrated that the use of a procalcitonin (PCT)-guided algorithm in combination with clinical judgment was associated with reduced antibiotic use without impacting mortality or

sepsis
antibiotic therapy
primary cancer
cancer
antimicrobial agent
  • 2 views
  • 26 Feb, 2021
  • 1 location