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Found 80 clinical trials
High Dose Inorganic Selenium for Preventing Chemotherapy Induced Peripheral Neuropathy

This study aims to evaluate the safety and efficacy of high dose inorganic selenium in preventing and relieving chemotherapy-induced peripheral neuropathy (CIPN) in platinum-sensitive recurrent ovarian, fallopian, or primary peritoneal cancer patients. This study will be conducted as a phase III randomized controlled trial in platinum-sensitive recurrent ovarian, fallopian, or …

paclitaxel
neuropathy
peripheral neuropathy
ovarian epithelial carcinoma
cancer chemotherapy
  • 1 views
  • 24 Jan, 2021
  • 1 location
Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for the Treatment of Resectable, Refractory, or Recurrent Abdominal or Pelvic Tumors in Pediatric Patients, T.O.A.S.T. I.T. Study

This early phase I trial studies how well heated intra-peritoneal chemotherapy with doxorubicin and cisplatin work for the treatment of abdominal or pelvic tumors that can be removed by surgery (resectable), does not respond to treatment (refractory), or has come back (recurrent). Heated intra-peritoneal chemotherapy is a procedure performed in …

cavity
renal function
tumor cells
doxorubicin
cytoreductive surgery
  • 1 views
  • 25 May, 2022
  • 1 location
A Study to Evaluate the Combination of ATX-101 and Platinum-based Chemotherapy

This is a Phase 1b/2a multicenter study, which consists of two parts: Part 1: the Phase 1b part of the study will investigate the safety of the combination of ATX-101 with carboplatin/pegylated liposomal doxorubicin (ACD). ATX-101 will be administered intravenously in three escalation cohorts: 20, 30, and 45 mg/m² according …

metastasis
carcinoma
platinum-based chemotherapy
ovarian epithelial carcinoma
doxorubicin
  • 0 views
  • 04 Oct, 2022
  • 5 locations
BrUOG 354 Nivolumab +/- Ipilimumab for Ovarian and Extra-renal Clear Cell Carcinomas

Preclinical and early-phase clinical data suggest that immune modulation represents a treatment strategy that is worthy of further investigation in relapsed epithelial ovarian cancer. One method by which tumor cells may evade immune surveillance is by activation of the programmed cell death (PD-1) pathway, mediated by expression of PD-1 on …

clear cell adenocarcinoma
metastasis
solid tumour
carcinoma
tumor cells
  • 129 views
  • 24 May, 2022
  • 4 locations
Phase II Clinical Trial of PLX038 in Patients With Platinum-Resistant Ovarian, Primary Peritoneal, and Fallopian Tube Cancer

This phase II trial tests whether pegylated SN-38 conjugate PLX038 (PLX038) works to shrink tumors in patients with ovarian, primary peritoneal, and fallopian tube cancers that has spread to other places in the body. PLX038 may stop the growth of tumor cells by blocking some of the enzymes needed for …

  • 0 views
  • 16 Oct, 2022
  • 1 location
Study of TTI-622 in Combination With PLD in Patients With Platinum-Resistant Ovarian Cancer

This is a multi-center, open-label study designed to evaluate TTI-622 administered in combination with Pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer. Approximately 50 patients will be enrolled in the study (this includes two phases, the Dose Escalation and Dose Expansion).

platinum-resistant ovarian cancer
neuropathy
carcinoma
ovarian cancer
ovarian epithelial carcinoma
  • 0 views
  • 04 Oct, 2022
  • 2 locations
Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

This phase Ib trial studies the best dose and side effects of niraparib and copanlisib in treating patients with endometrial, ovarian, primary peritoneal, or fallopian tube cancer that has come back. Niraparib and copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

neuropathy
lipase
carcinoma
parp inhibitor
tumor cells
  • 576 views
  • 07 Oct, 2022
  • 1 location
Dual mTorc Inhibition in advanCed/Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer (of Clear Cell, Endometrioid and High Grade Serous Type, and Carcinosarcoma) (DICE)

DICE is a randomised study recruiting 126 women over 3 years from hospitals in the UK and Germany. Eligible patients will have tissue based diagnosis of advanced/recurrent ovarian cancer (clear cell, endometrioid or high grade serous or carcinosarcoma), have had chemotherapy before, and be platinum-resistant (the cancer has returned/grown significantly …

serum pregnancy test
paclitaxel
metastasis
ovarian cancer
carcinosarcoma
  • 352 views
  • 16 Feb, 2022
  • 15 locations
Biomarkers for Early Detection of Ovarian Cancer Using Uterine Lavage

Screening programs for high-grade ovarian carcinoma failed to reduce disease-specific mortality, since they do not offer early enough detection of the disease. Most cases of high grade ovarian cancer develop in the fallopian tubes, hence the universal recommendation for high-risk populations (e.g., BRCA1/2 mutation carriers) is to undergo risk-reducing bilateral …

ovarian carcinoma
cavity
carcinoma
BRCA2
ovarian cancer
  • 8 views
  • 24 Jan, 2021
  • 5 locations
MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian, Fallopian, or Peritoneal Cancer

This randomized phase II trial studies how well oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) compared to investigator's choice chemotherapy works in treating patients with ovarian, fallopian, or peritoneal cancer. Measles virus, which has been changed in a certain way, may be able to kill tumor cells without …

paclitaxel
tumor cells
topotecan
doxorubicin
neutrophil count
  • 41 views
  • 24 Apr, 2022
  • 3 locations