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Found 240 clinical trials
Treatment Outcomes Among Patients With Prescription Narcotic Drug Use Disorder (TAPE)

This study follows up patients who receive standard treatment for prescription narcotic drug use disorder, including opioids, benzodiazepines, and benzodiazepine-like drugs (z-drugs), at a specialized addiction service. The overall goal is to evaluate the proportion of patients who reduce or cease using prescription narcotics and the factors associated with treatment …

drug use
drug abuse
  • 16 Feb, 2022
  • 1 location
Cardio-pulmonary Rehabilitation and Sleep Quality

In this prospective cohort study the investigators aim to evaluate the effect of pulmonary rehabilitation on sleep quality. Disturbed sleep is associated with, frequent exacerbations, increase in the severity of disease and increased mortality in chronic obstructive pulmonary disease (COPD). Sleep quality is a good predictor of quality of life …

pulmonary rehabilitation
heart failure
rehabilitation program
  • 19 Apr, 2022
  • 1 location
Novel EEG Coherence Biomarkers for PTSD Assessment

Current practice for diagnosing and managing PTSD relies primarily on subjective clinical assessments by clinicians as well as patient self-report. An independent, objective and neuro-physiology based method for directly assessing brain function is not available, but is much needed to improve diagnosis and management of PTSD. To address this critical …

Accepts healthy volunteers
  • 12 Apr, 2022
  • 1 location
Sleep and Insulin Resistance: The Impact of Gender Affirming Hormone Therapy in the Adolescent Transgender Population (ATP)

Disordered sleep is a health issue with significant impacts on physical and psychological well-being that has increased in prevalence, but its impact on transgender adolescents has not been fully quantified. While there is found to be an impact of sex steroids on sleep, and sex-dependent differences in the impact of …

Accepts healthy volunteers
  • 24 Oct, 2022
  • 1 location
Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

Background During the first few decades of life, the brain changes dramatically in shape and function. Sleep lets researchers measure these changes. Researchers want to create a database of sleep and neurodevelopmental data in a group of infants and children to learn more. Objective To address a knowledge and data …

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
The Predictive Value of Cervical Paraspinal Muscle Twitching During Motor Stimulation Testing on Cervical Facet Joint Radiofrequency Ablation Outcomes

The investigators aim to determine whether cervical paravertebral muscle twitching during motor testing as part of performing cervical RFAs is associated with a greater likelihood of treatment success, and greater magnitude or duration of analgesia. The investigators propose a straightforward grading scale based on visual and tactile information readily available …

  • 16 Oct, 2022
  • 1 location
Biological Function of Dreaming in Dreaming and Non-Dreaming Patients With PCA Infarction (BFD)

This study is a quasi-experimental between-group design. Using a prospective two-arm controlled exploratory study, data will be collected on an initial assessment of the effects of a specific neurological sample after thrombotic infarction (PCA infarction) who lost the ability to dream due to the infarction (experimental group) compared to a …

  • 25 Apr, 2022
  • 2 locations
Vulvovaginal Atrophy Questionnaire (VVAQ): Psychometric Validation of a Novel PROM

The goal of this study is to perform a quantitative assessment of the psychometric properties of the Vulvovaginal Atrophy Questionnaire (VVAQ), a novel patient reported outcome measure (PROM), through a REDCap survey of menopausal women with and without symptomatic vulvovaginal atrophy (VVA)/genitourinary syndrome of menopause (GSM).

  • 09 Apr, 2023
  • 1 location
CGRP Inhibition, Autonomic Function, and Migraine (CGRP-1)

The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e. whether they are between or during attacks) and whether the CGRP monoclonal antibody (mAb) …

Accepts healthy volunteers
  • 24 Apr, 2022
  • 1 location
Frailty and Postoperative Outcomes After Gastric Cancer Surgery (TOREGA)

Background. Gastric cancer is an important health care problem even though treatment advances, and it is diagnosed mainly in elderly. Surgery is the main treatment for gastric cancer and is associated with a high rate of postoperative complications and mortality, even higher in older patients. Chronological age seems not to …

cancer care
cancer surgery
  • 11 Apr, 2023
  • 1 location