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Found 240 clinical trials
SIESTA for Acute Stroke Rehabilitation (SIESTA-Rehab)

The SIESTA-Rehabilitation protocol combines two sleep-promoting interventions, (1) empowering nurses to reduce unnecessary disruptions and (2) a systematic protocol to screen, diagnose, and treat sleep-disordered breathing, to determine its impact on relevant sleep and rehabilitation outcomes in the acute inpatient stroke rehabilitation setting compared to the standard of care. Our …

sleep-disordered breathing
acute stroke
  • 25 Mar, 2022
  • 1 location
Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers (fMRIVNS)

The purpose of this research is to measure alterations in anxiety and brain activity associated with the use of an approved health device called Transauricular Vagal Nerve Stimulation (TaVNS) in distressed persons who work in a health care and distressed healthcare workers in the the Philadelphia, PA region. The Investigators …

Accepts healthy volunteers
  • 11 May, 2022
  • 1 location
Investigation of the Persistence of SARS-CoV-2 in the Olfactory Mucosa of Patients With Prolonged Symptoms of COVID-19 (NEUROCOVID)

NEUROCOVID is a prospective multicenter study comparing the proportion of patients with SARS-CoV-2 viral RNA at the level of the olfactory clefts in a group of cases compared to a group of controls as well as the correlations between the virological and cellular abnormalities observed in the olfactory mucosa and …

  • 04 Oct, 2022
  • 1 location
Optimal Treatment of Veterans With PTSD and Comorbid OUD

The objective of this study is to test a standard psychotherapy for PTSD in Veterans who also suffer from Opiate Use Disorder (OUD). Specifically, this study will test whether Cognitive Processing Therapy (CPT)-C is more effective in treating PTSD, compared to a control group (Individual Drug Counseling (IDC); which approximates …

structured clinical interview
cognitive therapy
  • 02 May, 2022
  • 2 locations
Evaluation of Transcranial Photobiomodulation in Autism Spectrum Disorder

The purpose of this 8-week double-blind randomized placebo-controlled study is to assess the tolerability, safety, and efficacy of tPBM in adult patients with ASD.

  • 09 Apr, 2023
  • 1 location
CBD Oil for Reducing Emotional Impact of COVID-19 (CBDOIL)

The overarching objective of the proposed project is to test the relative clinical efficacy of CBD isolate, full-spectrum CBD oil, broad-spectrum CBD oil, and placebo oil in reducing COVID-induced stress (anxiety, depression, anger, substance use, and sleep disturbance).

substance use
sleep problem
  • 15 Jun, 2022
  • 1 location
Effectiveness of Ecological Momentary Assessment Based Smoking Cessation Intervention

The EMA-based intervention in this proposal is aimed to motivate the majority of smokers who do not prefer to use traditional cessation aids for quitting and help them quit smoking. The smartphone application (app) and the EMA-based phone reminders at low cost and short intervention time make this approach attractive …

smoking cessation intervention
carbon monoxide
nicotine replacement
ecological momentary assessment
  • 20 Apr, 2022
  • 1 location
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will …

antiarrhythmic drug
  • 08 Jul, 2022
  • 1 location
Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea

The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between symptom phenotypes.

  • 22 Mar, 2022
  • 1 location
Evaluation of Self-efficacy as a Predictor for CPAP-compliance in a OSAS-patients French Cohort (SAFES)

during the first weeks of treatment. Biomedical factors, in particular nose respiratory abnormalities, somnolence complaints and insomnia complaints, have been widely studied but explain only 4 to

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location