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Found 859 clinical trials
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)

The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of glioblastoma). Glioblastoma is one of the most malignant cancers. TTFields is a new treatment for brain cancer …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Open-Label Extension and Safety Study of Talazoparib

This is a single-arm, open-label, extended treatment, safety study in patients treated with talazoparib in qualifying studies.

  • 424 views
  • 14 Feb, 2021
  • 42 locations
The Drug Rediscovery Protocol (DRUP Trial)

This is a prospective, non-randomized clinical trial that aims to describe the efficacy and toxicity of commercially available, targeted anticancer drugs* prescribed for treatment of patients with advanced cancer with a potentially actionable variant as revealed by a genomic or protein expression test. The study also aims to simplify patient …

pembrolizumab
erlotinib
solid tumor
sunitinib
liver metastasis
  • 260 views
  • 24 Jan, 2021
  • 16 locations
The Wessex Fit-4-Cancer Surgery Trial

Trial Phase: Phase III: A multi-centre efficacy pragmatic factorial design randomised controlled trial with patient informed development and process evaluation Indication: Patients undergoing major electively resectable intra - cavity cancer surgery with or without neoadjuvant cancer treatments (including chemotherapy (NAC), chemoradiotherapy (CRT), or immunotherapy). Objective: To investigate the efficacy of …

primary cancer
cancer surgery
dental caries
  • 3 views
  • 23 Jan, 2021
  • 1 location
A Study to Evaluate Safety Tolerability and Preliminary Efficacy of FP-1305 in Cancer Patients

This is a first in human study to identify whether FP-1305 is suitable to use in humans. The previous pre-clinical studies have demonstrated that FP-1305 binds to a receptor known as CLEVER-1. CLEVER-1 has been shown to support tumour growth. No significant adverse events were witnessed in primates and the …

primary cancer
carcinoma
breast cancer
metastasis
neutrophil count
  • 4 views
  • 27 Jan, 2021
  • 11 locations
Influence of PARAmedical Interventions on Patient ACTivation in the Cancer Care Pathway

The aim is to implement the Patient Activation Measure in paramedical practices as a tool to measure activation of patients in cancer care

primary cancer
cancer care
  • 0 views
  • 29 Jan, 2021
  • 12 locations
Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy

This randomized phase III trial studies how well olanzapine with or without fosaprepitant work in preventing chemotherapy induced nausea and vomiting in cancer patients receiving chemotherapy that causes vomiting. Olanzapine and fosaprepitant dimeglumine may help control nausea and vomiting in patients during chemotherapy. Olanzapine is usually given in combination with …

primary cancer
metastasis
emetics
dexamethasone
antibiotics
  • 109 views
  • 18 Feb, 2021
  • 579 locations
Predictive Markers of Immune-related Adverse Events in Patients Treated With Immune Stimulatory Drugs

The prospect of effective immunotherapies for the treatment of patients with cancer is now a clinical reality thanks to the approval of monoclonal antibodies (mAbs) specifically blocking immune checkpoints or ligands such as CTLA-4, PD-1 and PD-L1. However, these drugs can also induce inflammatory and/or auto-immune complications (Immune-related Adverse Events; …

primary cancer
combinations
monoclonal antibodies
pd-l1
immunosuppressive agents
  • 0 views
  • 22 Jan, 2021
Reproductive Health Program in Patients With Cancer

This clinical trial studies reproductive health program in patients with cancer. A reproductive health program may improve patients' understanding of reproductive risks and receipt of appropriate treatment to achieve their reproductive health goals

primary cancer
educational intervention
bilateral oophorectomy
  • 48 views
  • 25 Jan, 2021
  • 76 locations
Perioperative Risk Study

The primary objective of this trial is to determine if perioperative risk stratification and risk-based, protocol-driven management leads to a reduction in the rate of death or serious complications compared to standard perioperative management in patients undergoing elective major cancer surgery.

cancer surgery
pancreatectomy
cancer
gastrectomy
colectomy
  • 0 views
  • 27 Jan, 2021
  • 1 location