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Found 7 clinical trials
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

cardiopulmonary exercise testing
exercise stress test
stress test
endothelin
ralinepag
  • 4 views
  • 04 Oct, 2022
  • 36 locations
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Ralinepag When Added to PAH Standard of Care or PAH Specific Background Therapy in Subjects With WHO Group 1 PAH

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

beta-blocker
calcium channel blockers
calcium
endothelin
beta blockers
  • 6499 views
  • 28 Oct, 2022
  • 231 locations
Carnitine Consumption and Augmentation in Pulmonary Arterial Hypertension

In preparation for a future mechanistic study, investigators now propose to test the specific hypothesis that carnitine consumption is not reduced in PAH, that plasma carnitine levels are stable over time in PAH and that carnitine supplementation in PAH can increase plasma carnitine and thereby delivery of carnitine to the …

  • 0 views
  • 07 Oct, 2022
  • 1 location
Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension (T3PAH)

The main purpose of this clinical trial is to examine the feasibility and effects of tamoxifen in subjects with pulmonary arterial hypertension (PAH). The study will evaluate how well the drug is tolerated, and its impact on functional condition and selected biomarkers. Changes in tricuspid annular plane systolic excursion (TAPSE) …

tapse
connective tissue disease
hypertension
walk tests
  • 82 views
  • 04 Oct, 2022
  • 1 location
Hormonal, Metabolic, and Signaling Interactions in PAH

Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.

Accepts healthy volunteers
  • 51 views
  • 04 Oct, 2022
  • 1 location
Pulmonary Hypertension Biorepository and Registry

Establish a pulmonary hypertension registry and biorepository to lead towards a further understanding of the disease.

right heart catheterization
  • 0 views
  • 10 Jun, 2021
  • 2 locations
Comparison of PD1+T Cell Expression in Peripheral Blood for Cardiac Function Prognosis in Patients With Acute MI

Comparison of high PD1+ T cell and low PD1+ T cell expression in peripheral blood for cardiac function prognosis in Patients with acute myocardial infarction

Accepts healthy volunteers
  • 0 views
  • 13 Mar, 2022
  • 1 location