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Found 54 clinical trials
Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Severe aplastic anemia is a rare and serious form of bone marrow failure related to an immune-mediated mechanism that results in severe pancytopenia and high risk for infections and bleeding. Patients with matched sibling donors for transplantation have a 80-90% chance of survival; however, a response rate with just immunosuppression …

fludarabine
immunosuppression
graft versus host disease
total body irradiation
rabbit atg
  • 20 views
  • 18 Apr, 2022
  • 2 locations
Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-cell lung cancer

  • 0 views
  • 05 Jul, 2022
  • 32 locations
Preparation Regimens to Improve Capsule Endoscopy Visualization and Diagnostic Yield

Small bowel capsule endoscopy (SBCE) has become an important tool in clinical practice since its introduction in 2000. This non-invasive method allows the visualization of small bowel mucosa, being essential in the management of many conditions, such as suspected small bowel bleeding, inflammatory bowel diseases and intestinal polyposis syndromes. Despite …

  • 0 views
  • 10 Dec, 2021
  • 1 location
Comparative Effectiveness of Split-Dose Colonoscopy Bowel Preparation Regimens

From the patients' perspective, the most formidable part of the colonoscopy experience is the process of bowel cleansing. A poorly tolerated bowel preparation regimen often leads to incompletion of scheduled colonoscopies which in turn undermines the effectiveness of colonoscopy, increases cost, and decreases patient satisfaction. The current standard bowel preparation …

bowel preparation
  • 61 views
  • 28 Feb, 2022
  • 1 location
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

This is a treatment guideline for an unrelated umbilical cord blood transplant (UCBT) using a myeloablative preparative regimen for the treatment of hematological diseases, including, but not

hematologic disorder
fludarabine
raeb
imatinib
bone marrow procedure
  • 146 views
  • 25 Feb, 2022
  • 1 location
Personalized Targeted Preparative Regimen Before T-depleted Allogeneic HSCT in Children With Chemoresistent Acute Leukemias

The purpose of this study is to evaluate the safety and efficiency of personalized targeted therapy in combination with high-dose chemotherapy as part of a preparative regimen before T-depleted

  • 0 views
  • 26 Jan, 2021
  • 1 location
Allo HSCT Using RIC for Hematological Diseases

This is a phase II trial using a non-myeloablative cyclophosphamide/ fludarabine/total body irradiation (TBI) preparative regimen followed by a related or unrelated donor stem cell infusion. The

renal dysfunction
hematologic disorder
fludarabine
raeb
imatinib
  • 27 views
  • 24 Feb, 2022
  • 1 location
A Trial Comparing Single Agent Melphalan to Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) as a Preparative Regimen for Patients With Multiple Myeloma Undergoing High Dose Therapy Followed by Autologous Stem Cell Reinfusion (BEAM)

The work proposed herein aims to provide the first prospective, randomized comparative efficacy data between Melphalan and BEAM treatment regimen in the Multiple Myeloma (MM) patient population. The risk of such a study is deemed reasonable and ethical since: a) previous works have closely examined the safety and toxicity of …

etoposide
lymphoma
ejection fraction
plasmacytoma
bone marrow procedure
  • 0 views
  • 10 Jul, 2022
  • 1 location
Decitabine Plus mBU/CY Preconditioning for Relapse/Refractory Acute Leukemia

a preparative regimen for allo-HSCT using HLA-matching donors was safe and effective. In this prospective, single-arm clinical trial, we aimed to examine the efficacy of combining decitabine with

cyclophosphamide
cell transplantation
acute leukemia
busulfan
remission
  • 1 views
  • 09 Feb, 2022
  • 1 location
Decitabine Plus mBU/CY for High Risk Acute Leukemia With MRD Pre-HSCT

combination of decitabine, with busufan and cyclophosphamide as a preparative regimen for allo-HSCT using HLA-matching donors was safe and effective. In this prospective, single-arm clinical trial, we aimed

busulfan
residual tumor
cyclophosphamide
ara-c
minimal residual disease
  • 2 views
  • 01 Mar, 2022
  • 1 location