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Found 74 clinical trials
Intranasal Dexmedetomidine Versus Oral Midazolam as Premedication for Propofol Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging

, a retrospective study on the sedation protocol applied at Hôpital Universitaire des Enfants Reine Fabiola (H.U.D.E.R.F.) was conducted. In this protocol, premedication was done with oral midazolam

  • 0 views
  • 09 Apr, 2022
  • 1 location
a Phase III Trial of Safety and Efficacy of Premedication With Dexmedetomidine and Midazolam in Pediatric Patients

This research study to evaluate the relative efficacy of Dexmedetomidine, Midazolam, and compare them to the current KFSH&RC standard of care. Compare the safety and the frequency of adverse effects of treatment arms.

  • 0 views
  • 11 Mar, 2022
  • 1 location
Surfactant Administration by Insure or Thin Catheter (SAINT)

This trial evaluates the efficacy and safety of surfactant administration with thin catheter technique together with analgesic premedication in comparison with the established INSURE-strategy

premedication
continuous positive airway pressure
pulmonary surfactant
  • 0 views
  • 04 Jun, 2022
  • 1 location
A Phase I Study of ERY974 in Patients With Hepatocellular Carcinoma

, tolerability, pharmacokinetics, anti-tumor effect, and biomarkers of ERY974 in combination with atezolizumab and bevacizumab following premedication with tocilizumab in patients with locally advanced or

  • 0 views
  • 11 Jul, 2022
  • 6 locations
Multicohort Trial of Different Schemes of PM14 in Monotherapy and in Combination With Radiotherapy in Soft Tissue Sarcomas and Other Solid Tumor (PRIME)

progression or unacceptable toxicity. Premedication with dexamethasone is recommended on the day before treatment initiation. Cohort B A phase I dose-finding stage for PM14 is planned with an

  • 0 views
  • 10 Jul, 2022
  • 1 location
Efficacy of Montelukast in Reducing the Incidence and Severity of Monoclonal Antibodies Associated Infusion Reactions

premedication to decreasing the incidence and severity of infusion reaction. Most institutions have protocols using corticosteroid, acetaminophen and antihistamine as part of their premedication protocols. This

  • 63 views
  • 02 Mar, 2022
  • 1 location
The Effect of Pretreatment With Intravenous Lidocaine for Intravenous Contrast:

procedural sedation.Previous research has looked at premedication with steroids prior to IV-contrast media administration to avert an allergic response. However, there has been no investigation of

premedication
discomfort
pain assessment
lidocaine
  • 0 views
  • 23 Mar, 2022
  • 1 location
Multicohort Trial of Trabectedin and Low-dose Radiation Therapy in Advanced/Metastatic Sarcomas

withdrawal (day 2)) will be given every 3 weeks up to progression or intolerance. Premedication 4 mg oral dexamethasone 24h and 12h before trabectedin administration, 20 mg IV dexamethasone

soft tissue sarcoma
cancer chemotherapy
systemic therapy
anthracyclines
trabectedin
  • 0 views
  • 13 Dec, 2021
  • 11 locations
Pilot CAR-T Cells Therapy for Children/Young Adults With CD19+ R/R Leukemia/Lymphoma

The purpose of this study is to estimate the safety and the efficacy of CAR- T cells immunotherapy for children/young adults with relapsed or refractory acute lymphoblastic leukemia/lymphoma.

  • 0 views
  • 01 May, 2022
  • 1 location
Effect of Ocrelizumab on Brain Innate Immune Microglial Cells Activation in MS Using PET-MRI With 18F-DPA714 (INN-MS)

Ocrelizumab is a humanized anti-CD20 monoclonal antibody that showed in phase III trials a powerful effect on relapse rate and lesion load accumulation in the relapsing form of multiple sclerosis (RMS). This therapeutic agent also showed for the first time a significant reduction of disability progression in Primary Progressive Multiple …

secondary progressive multiple sclerosis
disease or disorder
natalizumab
nervous
myelopathies
  • 9 views
  • 01 Feb, 2022
  • 1 location