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Found 25 clinical trials
Featured trial
BIVV020 in Prevention and Treatment of Antibody-mediated Rejection (AMR)  

Primary Objectives: Cohort A: To evaluate the efficacy of BIVV020 in prevention of AMR Cohort B: To evaluate the efficacy of BIVV020 in treatment of active AMR Secondary Objectives: To assess the overall efficacy of BIVV020 in prevention or treatment of AMR To characterize the safety and tolerability of BIVV020 …

kidney transplant
  • 02 Feb, 2023
  • 20 locations
Featured trial
Adolescent BV - Impact of the vaginal microbiome on topical HIV pre-exposure prophylaxis (PrEP)

Through this study, we hope to learn how healthy bacteria and bacteria associated with a vaginal infection called bacterial vaginosis (BV) affect how PrEP works in women. BV is a common infection in young women that causes itching, odor, vaginal discharge, and inflammation. Women with BV may be at increased …

sexually transmitted infections
  • 23 Nov, 2020
  • 1 location
A Phase 2a Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of an Oral Tablet Formulation of JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis (SUMMIT)

The purpose of the study is to evaluate the efficacy of an oral tablet formulation of JNJ-77242113 compared with placebo in participants with moderate-to-severe plaque psoriasis.

  • 14 Oct, 2022
  • 33 locations
Mechanisms of Ozone-Induced Alterations in Efferocytosis and Phagocytosis

The purpose of this research study to understand how environmental and genetic factors may be involved in lung function. Healthy Study participants will undergo a 1-day screening that includes a blood draw and breathing testing, return for a two-day series of testing to include blood draw, and brief breathing test …

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
Sex Differences in Effectiveness of CBT on IBS Project 3 (U54_P3_CBT)

Cognitive Behavioral Therapy (CBT) is the most well researched and most effective treatment for IBS targeting the brain-gut-microbiome (BGM) axis, and preliminary data show that this therapeutic effect is associated with a reduction of brainstem connectivity with other brain networks. The increased prevalence of IBS in women, the higher rate …

  • 24 Mar, 2022
  • 1 location
A First in Human Study of the Menin-KMT2A (MLL1) Inhibitor JNJ-75276617 in Participants With Acute Leukemia

The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2D[s]) of JNJ-75276617 in Part 1 (Dose Escalation) and to determine safety and tolerability at the RP2D(s) in Part 2 (Dose Expansion).

acute leukemia
gilbert's syndrome
serum bilirubin level
direct bilirubin
  • 23 Oct, 2022
  • 23 locations
A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD (TRITON)

The purpose of this study is to compare CHF 5993 with CHF 1535 in improving lung function, reducing moderate and severe COPD exacerbations, and other clinical efficacy and safety outcomes in the target subject population.

  • 08 Jun, 2022
  • 8 locations
Couples Health CoOp Plus (CHC+)

This study addresses HIV prevention and treatment for young couples living in Cape Town, South Africa, through a comprehensive biobehavioral multilevel approach-the Couples Health CoOp Plus (CHC+). Through a cluster randomized trial with a modified factorial design, 24 Cape Town communities consisting of catchment areas for clinics that provide antiretroviral …

Accepts healthy volunteers
  • 19 Jun, 2022
  • 1 location
Improvement In Scratch Behavior And Sleep In Patients With Atopic Dermatitis (PAD)

This single blind study is to primarily evaluate wearable devices and Observer Reported Itch Assessment in children to assess reduction of itch and night-time scratch in response to Crisaborole treatment vs. vehicle treatment (active control comparator without crisaborole) in children with atopic dermatitis (AD). Participants, age 3 months to 5 …

crisaborole ointment
  • 04 Oct, 2022
  • 1 location
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

, calcium, magnesium, phosphorus). Pregnancy Tests: For women of childbearing potential, urine pregnancy testing will be done within the 24 hours prior to any MRI or PET scan. If the pregnancy test

depressed mood
depressive episode
  • 10 Oct, 2022
  • 1 location