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Found 137 clinical trials
Added Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis (PREMEO)

comorbidity-specific interventions, which fits well in the global move towards precision medicine. With a prevalence rate up to 50%, the presence of insomnia symptoms is a highly prevalent KOA comorbidity

behavior therapy
wake after sleep onset
cognitive behavioral therapy for insomnia
  • 17 Jun, 2022
  • 1 location
Brexpiprazole in Alcohol Use Disorder

. "Precision medicine" research has explored whether patient-level variables, such as genetic variation, may identify subgroups of individuals with larger medication effects, but few findings have been

psychiatric disorder
drug abuse
functional magnetic resonance imaging
  • 04 Oct, 2022
  • 1 location
Pharmacokinetics and Pharmacodynamics of Topiramate for Weight Loss in Youth: PHARMATOP (PHARMATOP)

National Institutes of Health (NIH) has recognized the importance of using precision medicine approaches in order to optimize treatments for pediatric severe obesity. Pharmacometrics, which uses

  • 22 Oct, 2022
  • 1 location
Brain Imaging Study on Biomarkers for Fibromyalgia

investigators will use advanced computational tools used for big data analysis and aim to identify factors that can be used as biomarkers and precision medicine tools.

Accepts healthy volunteers
sham treatment
chronic pain
  • 01 Mar, 2022
  • 1 location
Mechanistic Study of the Effect of ET-1 SNPs in Coronary Microvascular Disease

Zibotentan as a new drug treatment for patients with MVA using a 'precision medicine' approach. Zibotentan is a drug originally developed by Astra Zeneca for prostate cancer but prior research has shown

exercise stress test
exercise ecg
artery disease
  • 21 Oct, 2022
  • 1 location
Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity (EPSACO)

objective biomarkers of malignancy would be an advantage and would allow better progress in the field of precision medicine and surgery for these tumors. The investigators propose to establish the

  • 12 Apr, 2023
  • 1 location
Parent-implemented Social Communication Treatment in Preschool Children With Autism Spectrum Disorder

response, which will increase the likelihood of these models being generalizable to new patients. This study will be among the first examples of fulfilling the promise of Precision Medicine in

  • 04 Oct, 2022
  • 2 locations
Biomechanical and Neural Mechanisms of Post-stroke Gait Training

The study seeks to develop an understanding of how, why, and for whom fast treadmill walking (Fast) and Fast with functional electrical stimulation (FastFES) induce clinical benefits, allowing future development of cutting-edge, individually-tailored gait treatments that enhance both gait quality and gait function.

gait training
electrical stimulation
ischemic stroke
  • 19 Apr, 2021
  • 1 location
Effects of Obesity and Intensity of Exercise on Ghrelin Levels

This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.

Accepts healthy volunteers
insulin sensitivity
  • 30 May, 2022
  • 1 location
A Phase 2 Safety, Dose-finding and Efficacy Study Evaluating Viscoelastic Testing (VET) Guided Tissue Plasminogen Activator (tPA) Treatment in Critically-ill Pro-thrombotic Acute Respiratory Failure (VETtiPAT-ARF)

Patients with coronavirus disease (COVID) and non-COVID acute respiratory failure (ARF) may be at an increased risk of thrombosis due to increased clot formation and decreased clot lysis. This two stage study aims to utilise bedside coagulation technology to detect patients at increased risk and guide tPA treatment to maximise …

  • 17 Oct, 2022
  • 1 location