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Found 151 clinical trials
Featured trial
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person. Researchers want to see if this therapy fights kidney cancer cells. Metastatic renal cell …

clear cell carcinoma
primary cancer
metastatic cancer
clear cell renal cell carcinoma
  • 22 Dec, 2020
  • 1 location
Evaluating a Novel Individualised Treatment Strategy for Carbapenem-Resistant Gram-Negative Bacteria Infections

Carbapenem-resistant (CR) Gram negative bacteria (GNB) - which are resistant to carbapenems (a last-line potent antibiotic with a high therapeutic index) - are also resistant to all other beta-lactam antibiotics. Most CRGNB are also extensively-drug resistant (XDR) (resistant to all classes of antibiotics except polymyxins and/or tigecycline) or pan-drug resistant …

  • 21 Feb, 2022
  • 1 location
PRIME Care (PRecision Medicine In MEntal Health Care) 2.0

Background: In the last several years, commercial pharmacogenetic (PGx) testing for the selection of psychotropic medications has become widespread as a means of implementing "precision medicine

  • 21 Jul, 2021
  • 1 location
Mindfulness-Oriented Recovery Enhancement (MORE) in Heroin Addiction

that can be used for enhancing precision medicine with the goal of reducing morbidity and mortality associated with opiate addiction.

  • 25 Jan, 2021
  • 1 location
Precision Guided Tacrolimus Dosing in Pediatric Heart Transplant

elimination of these agents. The goal of this research proposal is to clinically validate an innovative precision medicine strategy for dosing the immunosuppressant tacrolimus in pediatric heart transplant

  • 19 Jun, 2022
  • 2 locations
Myeloma-Developing Regimens Using Genomics (MyDRUG) (MyDRUG)

The MyDRUG study is a type of Precision Medicine trial to treat patients with drugs targeted to affect specific genes that are mutated as part of the disease. Mutations in genes can lead to

  • 07 Feb, 2022
  • 13 locations
Pharmacokinetics and Pharmacodynamics of Topiramate for Weight Loss in Youth: PHARMATOP (PHARMATOP)

National Institutes of Health (NIH) has recognized the importance of using precision medicine approaches in order to optimize treatments for pediatric severe obesity. Pharmacometrics, which uses

  • 11 May, 2022
  • 1 location
Functional Precision Oncology for Metastatic Breast Cancer (FORESEE)

This is a pilot study to assess the feasibility of comprehensive genomic characterization and drug screening in metastatic breast cancer. The trial will seek to provide personalized genomic and drug sensitivity information to eligible patients with metastatic breast cancer prior to disease progression on standard treatment. The trial will also …

  • 20 Jun, 2022
  • 1 location
MBSR Mechanisms in GAD

The purpose of this study is to understand the neural mechanisms that drive response to MBSR compared to stress education in patients with generalized anxiety disorder (GAD), and to examine the degree to which sex differences in MBSR response are explained by sex differences in these mechanisms. A total of …

  • 14 Apr, 2022
  • 1 location
Targeting the Gut-brain Axis to Facilitate Weight Loss in High Fat Diet Consumers

The primary objective is to test if fat intake moderates the ability of Oleoylthanolamide (OEA) to improve weight loss maintenance after the LEARN weight loss program.

  • 12 Nov, 2021
  • 1 location