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Found 633 clinical trials
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Characterizing Long-term Cognitive and Emotional Impairment in Post-COVID-19 Sequelae

Weeks and months after they have seemingly recovered from COVID-19, many patients continue to suffer from major long-term effects. While the virus typically hits the respiratory system, accumulating evidence now indicates a variety of other, non-respiratory symptoms, some of which manifest long after recovery from the acute phase of the …

  • 0 views
  • 16 May, 2021
  • 1 location
None
Quality of Life Fatigue and Cognitive Affective and Emotional Dysfunction in Patients With Cushing's Syndrome

This is a prospective, multi-center, case-control study where neurocognitive function will be evaluated in 36 patients with Cushing syndrome (CS) and 36 controls matched for age, gender and education.

adenoma
adrenal adenoma
fatigue
corticotropin
  • 59 views
  • 02 Jul, 2021
  • 3 locations
None
Patient-specific Effective and Rational Functional Connectivity Targeting for DBS in OCD

The study aims to improve patient-specific anatomical targeting of the Deep Brain Stimulation for the treatment of intractable OCD.

  • 0 views
  • 16 Apr, 2021
  • 1 location
None
The Dutch Parkinson and Cognition Study

Parkinson Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. The DUPARC study is a single-centre longitudinal cohort study aimed at deeply phenotyping newly diagnosed PD patients. The main aim is to investigate the relationship between cognitive impairment and both …

neurodegenerative disorders
motor symptoms
cognitive impairment
  • 6 views
  • 23 Jan, 2021
  • 1 location
None
Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride

Patients with bicuspid aortic valve-related aortopathy are at increased risk of aortic dilatation, dissection and rupture. Currently, risk stratification is largely based on aortic diameter measurements, with those deemed high risk referred for aortic replacement surgery. This approach is imperfect, and potentially exposes many patients to unnecessary high-risk aortic surgery, …

  • 0 views
  • 05 May, 2021
  • 1 location
None
Impact of Coronary Artery Stenting on Quantitative Myocardial Blood Flow and Health Status

We propose to perform PET MPI studies in patients before and after stenting to evaluate changes (or lack thereof) in MBFR and how that is associated with changes (or lack thereof) in symptoms, functional status and quality of life. This will help to understand the role of MBFR in patient …

angiography
angina pectoris
regadenoson
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Atlas of Retinal Imaging in Alzheimer's Study

The Atlas of Retinal Imaging in Alzheimer's (ARIAS) study is a 5-year study examining the natural history of retinal imaging biomarkers associated with disease risk, disease burden, and disease progression in Alzheimer's disease (AD). The objective of this project is to create a 'gold standard' reference database of structural anatomic …

depression
neuropsychological test
mild cognitive impairment
cognitive impairment
eye exam
  • 0 views
  • 25 Jan, 2021
  • 4 locations
None
Novel MRI Assessment of Prostate Cancer VALIDATE-PRO

For 50 years the diagnosis of prostate cancer has been with Prostate Specific Antigen (PSA) blood testing and prostate biopsy. However, this approach resulted in over-diagnosis, over-treatment and missed clinical important cancers. Multi-parametric MRI (mp-MRI) has provided a solution to some of these issues and the National Institute for health …

  • 0 views
  • 31 Aug, 2021
  • 1 location
None
Intervention to Hepatic and Pulmonary Metastasis in Breast Cancer Patients

The number of intervention performed for metastatic breast cancer has dramatically increased over the past 2 decades. Hepatectomy and pulmonary resection for stage IV colorectal cancer is now considered the standard of care for resectable patients with isolated hepatic and/or pulmonary disease and acceptable performance status. However, the indications for …

cancer
stereotactic radiosurgery
metastasis
hepatectomy
radiofrequency ablation
  • 215 views
  • 23 Jan, 2021
  • 1 location
None
Biodynamic Imaging Utility in Predicting Response to Gemcitabine Chemotherapy in Mycosis Fungoides

This is a single-arm, non-randomized feasibility study designed to find out if the laser light-based imaging test called Biodynamic imaging (BDI) can correctly predict the cutaneous T-cell lymphoma mycosis fungoides (MF) cancer response to chemotherapy treatment. The primary objective is to develop phenotypic profiles of response and non-response to gemcitabine, …

cancer
t-cell lymphoma
metastases
mycosis
systemic therapy
  • 2 views
  • 26 Nov, 2021
  • 1 location