Found 589 clinical trials
AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
216 weeks of treatment (A45 Trial) and to determine whether treatment with BAN2401 is superior to placebo in reducing brain amyloid accumulation as measured by amyloid positron emission tomography
- 26 views
- 29 Aug, 2022
- 4 locations
Ketamine for the Treatment of Depression in Parkinson's Disease (KET-PD) (KET-PD)
The main purpose of this study is to examine the efficacy and safety of a repeated dosing ketamine infusion paradigm compared to placebo in individuals with PD. A subset of participants in each arm will undergo baseline and post-treatment PET and fMRI scans, to examine whether changes in synaptic density …
- 36 views
- 17 Sep, 2022
- 1 location
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma(CLL/SLL), Lymphoplasmacytic Lymphoma(LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma(SMZL)
drawn. When required patients may undergo additional testing that may include bone marrow biopsy and aspiration, blood drawing, lymph node biopsy, x-ray studies, positron emission tomography and CT and
- 115 views
- 15 Apr, 2019
- 1 location
A PHASE III, MULTICENTER, RANDOMIZED, PARALLEL-GROUP, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF GANTENERUMAB IN PARTICIPANTS AT RISK FOR OR AT THE EARLIEST STAGES OF ALZHEIMER’S DISEASE
This study is designed to evaluate the efficacy and safety of Gantenerumab in participants at risk for or at the earliest stages of Alzheimer’s Disease (AD)
- 4 views
- 24 Jun, 2022
- 1 location
Cardiovascular Disease Discovery Protocol
>Positron emission tomography (PET) imaging to study possible fat infiltration of the heart Six-minute walk test to study heart, lung, and muscle function and performance Vascular ultrasound
- 613 views
- 08 Apr, 2019
- 1 location
Proteins and Brain Networks in Atypical Alzheimer's Disease
Participants will take part in 2-4 study visits including detailed history and neurological exam, pen-&-paper cognitive testing, and functional MRI and PET scans designed to help us understand how different forms of Alzheimer's disease affect brain circuits over time.
- 53 views
- 24 Jan, 2022
- 1 location
PSMA-PET Registry for Recurrent Prostate Cancer (PREP)
This study aims to institute a province-wide registry leveraging the availability of a new Positron Emission Tomography tracer, [18F]-DCFPyL and PET expertise across Ontario centers to improve
- 108 views
- 15 Feb, 2022
- 6 locations
Study to Assess the Efficacy and Safety of 2 Dosage Regimens of Oral IPN60130 for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). (FALKON)
15 years of age or older are also eligible for a sub study to evaluate HO lesions assessed by another type of scan, Fluorine-18-labelled natrium fluoride Positron Emission Tomography-Computed
- 0 views
- 25 Jul, 2022
- 12 locations
A Randomized Phase 3 Trial of Nivolumab (NSC# 748726) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma
This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells …
- 61 views
- 19 Sep, 2022
- 92 locations
18F-Fluorocholine Positron Emission Tomography (PET) for the Detection of Parathyroid Adenomas
This is a prospective single arm single center Phase III study evaluating the ability of 18F-fluorocholine to detect the location of parathyroid adenomas.
- 0 views
- 26 Aug, 2021
- 2 locations