Found 511 clinical trials
AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
216 weeks of treatment (A45 Trial) and to determine whether treatment with BAN2401 is superior to placebo in reducing brain amyloid accumulation as measured by amyloid positron emission tomography
- 44 views
- 18 Jul, 2023
- 5 locations
Ketamine for the Treatment of Depression in Parkinson's Disease (KET-PD)
The main purpose of this study is to examine the efficacy and safety of a repeated dosing ketamine infusion paradigm compared to placebo in individuals with PD. A subset of participants in each arm will undergo baseline and post-treatment PET and fMRI scans, to examine whether changes in synaptic density …
- 46 views
- 07 Oct, 2022
- 1 location
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma(CLL/SLL), Lymphoplasmacytic Lymphoma(LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma(SMZL)
drawn. When required patients may undergo additional testing that may include bone marrow biopsy and aspiration, blood drawing, lymph node biopsy, x-ray studies, positron emission tomography and CT and
- 115 views
- 15 Apr, 2019
- 1 location
A PHASE III, MULTICENTER, RANDOMIZED, PARALLEL-GROUP, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF GANTENERUMAB IN PARTICIPANTS AT RISK FOR OR AT THE EARLIEST STAGES OF ALZHEIMER’S DISEASE
This study is designed to evaluate the efficacy and safety of Gantenerumab in participants at risk for or at the earliest stages of Alzheimer’s Disease (AD)
- 4 views
- 24 Jun, 2022
- 1 location
Cardiovascular Disease Discovery Protocol
>Positron emission tomography (PET) imaging to study possible fat infiltration of the heart Six-minute walk test to study heart, lung, and muscle function and performance Vascular ultrasound
- 613 views
- 08 Apr, 2019
- 1 location
Participants Needed: Brain Imaging Research Study on Alzheimer’s Disease and Mild Cognitive Impairment
Participants diagnosed with Alzheimer’s Disease (AD) or Mild Cognitive Impairment (MCI) will receive an amyloid PET scan to help confirm AD diagnosis, as well as other noninvasive brain imaging (MEG and MRI) and cognitive assessments. The goals of this study are to determine how AD and MCI affect brain activity …
- 6 views
- 18 Jul, 2023
- 1 location
Longitudinal Investigation of I2BS in PD (FOX_2)
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic
- 4 views
- 16 Mar, 2023
- 1 location
Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
performing two Positron Emission Tomography (PET) scans using the tracer [11C]PBR28, that takes pictures of the brain highlighting the areas of inflammation, before and after the administration of a compound
- 0 views
- 17 Mar, 2023
- 1 location
PSMA-PET Registry for Recurrent Prostate Cancer (PREP)
This study aims to institute a province-wide registry leveraging the availability of a new Positron Emission Tomography tracer, [18F]-DCFPyL and PET expertise across Ontario centers to improve
- 108 views
- 04 Apr, 2023
- 6 locations
A Study to Assess the Effectiveness and Safety of 2 Dosage Regimens of Oral Fidrisertib (IPN60130) for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). (FALKON)
years of age or older are also eligible for a sub study to evaluate HO lesions assessed by another type of scan, Fluorine-18-labelled natrium fluoride Positron Emission Tomography-Computed Tomography
- 0 views
- 01 Oct, 2023
- 20 locations