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Found 107 clinical trials
Neurocognition After Perturbed Sleep (NAPS)

Individuals with schizophrenia display a wide range of neurocognitive difficulties resulting in functional impairment and disability. Extensive evidence indicates insomnia and sleep disturbances play a substantial role in degrading cognitive functioning. However, the putative impact of insomnia and sleep disturbances on neurocognition and daily functioning has not been investigated in …

schizophreniform disorder
antipsychotics
  • 0 views
  • 19 Apr, 2022
  • 1 location
Effects of Bright Light on Co-occurring Cancer-related Symptoms in Breast Cancer Survivors

This study will implement therapeutic bright light that is tailored to the individual's circadian typology and will estimate its effects on circadian rhythms, 4 common cancer-associated symptoms, and impact on quality of life in survivors living with cancer. Examining a selected phase marker (core body temperature) in relation to the …

Accepts healthy volunteers
  • 1 views
  • 11 Jul, 2022
  • 1 location
Comparative Analysis Between Sleeve Gastrectomy and Roux-en Y Gastric Bypass in Bariatric Operation

Prospective, double-arm, multi-center cohort study on obese patients, for laparoscopic sleeve gastrectomy versus Roux-en Y gastric bypass

  • 0 views
  • 26 Jan, 2021
  • 1 location
Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia (R01)

The study is a three phase sequential study of the medical treatment of insomnia with zolpidem. All participating subjects will receive one month of standard nightly treatment. If the subject has a positive treatment response they continue in the study and are randomized to one of four conditions: intermittent dosing …

behavior therapy
chronic insomnia
cbt-i
cognitive behavioral therapy for insomnia
zolpidem
  • 60 views
  • 23 Jul, 2022
  • 1 location
Hyperandrogenemia and Altered Day-night LH Pulse Patterns (CRM008)

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone pulse frequency (primary endpoint).

hirsutism
hyperandrogenism
spironolactone
testosterone
androgens
  • 68 views
  • 29 May, 2022
  • 1 location
Understanding Trauma Nightmares Using In-Home Measurement

Trauma-related nightmares in Veterans are associated with poor clinical outcomes, greater substance use, and increased risk of suicide. In spite of an urgent need to reduce the burden of trauma-related nightmares, the underlying physiological changes associated with them are poorly understood, and there are no clear evidence-based recommendations for their …

substance use
nightmares
  • 96 views
  • 21 Mar, 2022
  • 1 location
MGH Trauma-related Nightmares SDI Study (NM)

Interested individuals will first complete a telephone screening followed by a series of structured clinical interviews to diagnose PTSD and comorbid psychiatric disorders, confirm initial inclusion criteria, rule out exclusion criteria and create an audio-recorded account of their index trauma. Participants passing screenings will then complete 2 weeks of at-home …

nightmares
violence
serious injury
  • 0 views
  • 11 Jul, 2022
  • 1 location
Sleep and Emotional Memory in Peripubertal Anxiety

The current study aims to deepen understanding of the symptom dimension of negative overgeneralization in anxiety. Specifically, the study examines the malleability of memory processes that are known to occur during sleep that may underlie negative overgeneralization.

social phobia
Accepts healthy volunteers
anxiety
separation anxiety
generalized anxiety
  • 107 views
  • 27 Apr, 2022
  • 2 locations
Exercise and Sleep in Parkinson's Disease

This study will investigate the impact of two common exercise modalities, cardiovascular and resistance training, on sleep quality and architecture in persons with Parkinson's disease (PD), and whether these potential positive changes in sleep are associated with improvements in brain plasticity and different quality of life (QoL)-related aspects. Participants will …

Accepts healthy volunteers
  • 0 views
  • 24 Apr, 2022
  • 1 location
SmART-TBI: Supplementation With Amino Acid Rehabilitative Therapy in TBI (SmART-TBI)

The most persistent and disabling postconcussive symptoms following mild traumatic brain injury (mTBI) are sleep disturbances and cognitive dysfunction, with few tractable interventions currently available. Here, a novel therapy will be tested consisting of dietary supplementation with branched chain amino acids (BCAA), based on the study team's previous preclinical work …

sedative
  • 20 views
  • 04 Jun, 2022
  • 1 location