Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 117 clinical trials
Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia

This study aims to evaluate the effect of Suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia. The investigator's central hypothesis is that Suvorexant will reduce sympathetic nerve activity and improve baroreflex function when compared to placebo.

suvorexant
body mass index
chronic insomnia
  • 67 views
  • 26 Jan, 2021
  • 3 locations
Bright Light Therapy as Possible Treatment Option for MS-Fatigue

This study aims to investigate the effect of a 2-week trial of bright light therapy (BLT, 10.000 lx) on fatigue in multiple sclerosis (MS) patients. In this randomised placebo-controlled trial, the effect of bright light therapy will be compared to dim red light. MS-fatigue is quantified by patients using a …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Sleep Apnea-Hypopnea Syndrome and the Pathogenesis of Obesity

The hypothesis of the study is the following: Patients with sleep apnea-hypopnea syndrome have different pattern in the secretion of hormones. The chronic sleep disorganization that suffer patients with sleep apnea-hypopnea syndrome (SAHS) may affect the central mechanisms that regulate nutritive behavior and energetic balance, causing an alteration in the …

body mass index
obstructive sleep apnea
apnea-hypopnea index
continuous positive airway pressure
hypopnea syndrome
  • 200 views
  • 07 Nov, 2020
  • 1 location
Combination Therapy Associating CPAP and Mandibular Advancement Device in OSA

The aim of this study is to evaluate the efficacy of a combination of Continuous Positive Airway Pressure (CPAP) and a Mandibular Advancement Device (MAD) on nocturnal Blood Pressure control in hypertensive patients in obstructive sleep apnea low CPAP compliers (less than 4 hours per night). Hypertensive patients demonstrating low …

ambulatory blood pressure monitoring
sleep apnea
obstructive sleep apnea
mandibular advancement
continuous positive airway pressure
  • 1 views
  • 17 Feb, 2021
  • 5 locations
Validation of Sleep Questionnaires in the Down Syndrome Population

This will be a prospective validation study of a sample of consecutive pediatric Down syndrome patients who are seen through the weekly Down syndrome clinic at OHSU/Doernbecher's. Questionnaires will be administered to approximately 5 new patients per month. Since this population has a higher prevalence of OSA than the general …

polysomnography
  • 0 views
  • 26 Jan, 2021
  • 1 location
Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD

In the present study, we examine the question “Will day-time aggression in children improve when their night-time sleep is treated with pharmacological intervention (i.e. clonidine)?” There is considerable anecdotal evidence that clonidine may provide an effective alternative to neuroleptics for treating aggression in children -- first by improving the overall …

attention deficit hyperactivity disorder
tourette's syndrome
hyperactivity
attention deficit disorder
clonidine
  • 57 views
  • 07 Nov, 2020
  • 1 location
Effects of Weight Loss on Vascular Function in Obese Subjects

To evaluate the effect of weight loss on vascular function in obese with poor cardiovascular health. The investigators will evaluate the effects of weight loss on total and central body adiposity, blood pressure, central hemodynamic parameters, arterial stiffness, endothelial function, apnea-hypopnea index, insulin resistance and inflammatory markers.

insulin resistance
insulin
body mass index
  • 0 views
  • 24 Jan, 2021
  • 2 locations
Sleep Thermography for Diagnosis of Obstructive Sleep Apnea (TERMOAPNEA)

To assess the diagnostic validity and cost-effectiveness of an infrared thermography system in adults with clinical suspicion of Obstructive Sleep Apnea (OSA).

  • 1 views
  • 24 Jan, 2021
  • 1 location
Platelet Activation and Circadian Rhythms of Clotting-Fibrinolysis Factors in Patients With Sleep Apnea Syndrome

The objective of the study is to define and compare clotting- fibrinolysis patterns, platelet function markers and endothelial dysfunction in patients with SAHS before and after treatment and normal controls age and weight matched.

platelet aggregation
obstructive sleep apnea
apnea-hypopnea index
continuous positive airway pressure
endothelial dysfunction
  • 47 views
  • 07 Nov, 2020
  • 1 location
Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea

Currently, there is no pharmacological intervention for OSA that targets multiple pathophysiological deficits in combination. Here the investigators study the effect on sleep apnea severity of combinations of pharmacological agents that stimulate the pharyngeal muscles, stabilize ventilatory control, and increase the arousal threshold.

obstructive sleep apnea
  • 6 views
  • 27 Jan, 2021
  • 2 locations