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Found 127 clinical trials
Obstructive Sleep Apnea and Telomere Length

questionnaires, polysomnography and blood collection for DNA and extraction and measurement of telomere length, as well as the expression of telomerase and oxidative and inflammatory markers (ADMA, homocysteine

  • 14 May, 2021
  • 1 location
Medications for Obstructive Sleep Apnea In Children With Down Syndrome

This is a randomized, double blind, cross-over study of the combination of atomoxetine and oxybutynin (ato-oxy) in children with DS and OSA documented by polysomnography (PSG). Participants will

apnea-hypopnea index
  • 25 Jan, 2021
  • 1 location
A Cardiosleep Research Program on Obstructive Sleep Apnea Blood Pressure Control and Maladaptive Myocardial Remodeling

cardiovascular risk by blood pressure reduction in East Asians. We will recruit East Asian subjects with hypertension and high cardiovascular risk for polysomnography. Patients diagnosed with OSA (n=220

oral appliances
continuous positive airway pressure
mandibular advancement
chronic kidney disease
  • 21 Feb, 2021
  • 1 location
Efficacy of Intra-oral Neuromuscular Stimulation Training on Snoring and Mild Sleep Apnoea

snoring and improve sleep quality. This will be achieved by participants using the eXciteOSA once daily for a six week period. A two night sleep study with watchPAT along with a polysomnography

  • 27 Jan, 2021
  • 3 locations
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD and After Adenotonsillectomy.

sleep factors (apnea-hypopnea index, obstructive apnea index, arousal index, mean and least oxygen saturation, and sleep stage; assessed by polysomnography) between the OSA with ADHD group (Study Group

  • 05 Feb, 2021
  • 1 location
The Interplay Between Addiction to Tobacco Smoking and Sleep Quality Among Healthy Adults

polysomnography (PSG), pulmonary function test, biological markers of stress (cortisol and -amylase) and smoking (i.e., cotinine, the main metabolite of nicotine), and emotional and cognitive functioning via

nicotine dependence
nicotine product
poor sleep
  • 23 Jan, 2021
  • 1 location
Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement

Sleep apnea including obstructive sleep apnea (OSA) and central sleep apnea (CSA), are common in patients with cardiovascular disease. The prevalence of OSA is 2%-4% in general population and 16%-47% in surgical-heart failure patients. The previous studies found that the sleep apnea types shifted from OSA to CSA after continuous …

heart surgery
heart disease
valvular disease
cardiovascular disease
heart failure
  • 19 Mar, 2021
  • 1 location
Sleep Apnea in Cerebrovascular Disease

This study seeks to evaluate a diagnostic and therapeutic intervention strategy among veterans with cerebrovascular disease, hypertension and obesity that consists of using unattended sleep studies to diagnose sleep apnea and CPAP to treat sleep apnea. It is hypothesized that the intervention strategy will (1) reduce hypertension at the end …

sleep apnea
  • 07 Nov, 2020
  • 1 location
Acetazolamide Add-On Therapy to OSA Surgery

Surgical procedures are routinely performed as an alternative to continuous positive airway pressure treatment in patients with obstructive sleep apnea (OSA). However, the response to surgery is often variable. Instability of the respiratory control during sleep (or high loop gain) has been associated with poor surgical results in previous research. …

continuous positive airway pressure
  • 24 Jan, 2021
  • 1 location
Optimal Dosage of Acetazolamide for OSA Treatment

Acetazolamide, a carbonic anhydrase inhibitor, has received some attention as potential treatment for obstructive sleep apnea (OSA). It produces a metabolic acidosis by excreting bicarbonate, thereby stimulating baseline ventilation. Evidence suggests that acetazolamide primarily improves ventilatory control instability (expressed as loop gain), which is an important contributor to the pathophysiology …

  • 30 May, 2021
  • 1 location