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Found 112 clinical trials
Sleep Apnea in Cerebrovascular Disease

This study seeks to evaluate a diagnostic and therapeutic intervention strategy among veterans with cerebrovascular disease, hypertension and obesity that consists of using unattended sleep studies to diagnose sleep apnea and CPAP to treat sleep apnea. It is hypothesized that the intervention strategy will (1) reduce hypertension at the end …

sleep apnea
  • 07 Nov, 2020
  • 1 location
Optimal Dosage of Acetazolamide for OSA Treatment

Acetazolamide, a carbonic anhydrase inhibitor, has received some attention as potential treatment for obstructive sleep apnea (OSA). It produces a metabolic acidosis by excreting bicarbonate, thereby stimulating baseline ventilation. Evidence suggests that acetazolamide primarily improves ventilatory control instability (expressed as loop gain), which is an important contributor to the pathophysiology …

  • 30 May, 2021
  • 1 location
Noninvasive Peripheral Nerve Stimulation for Medication-Naive and Medication-Refractory RLS

Prospective multi-site randomized sham-controlled study evaluating tolerability and efficacy of noninvasive peripheral nerve stimulation (NPNS) for patients with moderate-severe primary Restless Legs Syndrome (RLS) who are either medication-naive or medication-refractory.

  • 14 May, 2022
  • 2 locations
Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia

This study aims to evaluate the effect of Suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia. The investigator's central hypothesis is that Suvorexant will reduce sympathetic nerve activity and improve baroreflex function when compared to placebo.

chronic insomnia
body mass index
  • 04 Feb, 2022
  • 1 location
Obstructive Sleep Apnea and Comprehensive Remotely-supervised Rehabilitation Program

The purpose of this study is to investigate the feasibility and effect of a 12-week remotely-supervised rehabilitation program in male patients between 30-60 years old with newly diagnosed obstructive sleep apnea with Apnea-Hypopnea Index greater than 15 episodes per hour indicated to CPAP therapy.

  • 07 May, 2022
  • 1 location
Validation of Sleep Questionnaires in the Down Syndrome Population

This will be a prospective validation study of a sample of consecutive pediatric Down syndrome patients who are seen through the weekly Down syndrome clinic at OHSU/Doernbecher's. Questionnaires will be administered to approximately 5 new patients per month. Since this population has a higher prevalence of OSA than the general …

Accepts healthy volunteers
  • 21 Mar, 2022
  • 1 location
Effects of Weight Loss on Vascular Function in Obese Subjects

To evaluate the effect of weight loss on vascular function in obese with poor cardiovascular health. The investigators will evaluate the effects of weight loss on total and central body adiposity, blood pressure, central hemodynamic parameters, arterial stiffness, endothelial function, apnea-hypopnea index, insulin resistance and inflammatory markers.

insulin resistance
body mass index
Accepts healthy volunteers
  • 20 Feb, 2022
  • 2 locations
Sleep Thermography for Diagnosis of Obstructive Sleep Apnea (TERMOAPNEA)

To assess the diagnostic validity and cost-effectiveness of an infrared thermography system in adults with clinical suspicion of Obstructive Sleep Apnea (OSA).

  • 26 Sep, 2021
  • 1 location
Improving Outcomes for Patients With SDB and Insufficient Sleep

The purpose of this study is to look at how mild sleep disordered breathing (SDB), and not getting enough sleep each night, contribute to daytime sleepiness. The investigators also want to determine the treatment that works best for improving daytime sleepiness. In this study, the investigators are comparing 3 programs …

apnea-hypopnea index
total sleep time
sleep-disordered breathing
  • 18 Aug, 2021
  • 1 location
Assessment of Continuous Positive Airway Pressure Therapy in IPF (ACT-IPF)

The purpose of this study is to evaluate whether biomarkers of lung injury and remodeling are responsive to effective continuous positive airway pressure (CPAP) treatment in adults with idiopathic pulmonary fibrosis (IPF) and moderate-to-severe obstructive sleep apnea (OSA).

pulmonary fibrosis
idiopathic pulmonary fibrosis
  • 13 Apr, 2022
  • 1 location