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Found 80 clinical trials
Improving Outcomes for Patients With SDB and Insufficient Sleep (RESTORE)

The purpose of this study is to look at how sleep disordered breathing (SDB) and not getting enough sleep each night contribute to daytime sleepiness. The investigators also want to determine the treatment that works best for improving daytime sleepiness. In this study, the investigators are comparing 2 programs that …

sleep-disordered breathing
self monitoring
Accepts healthy volunteers
apnea-hypopnea index
  • 04 Oct, 2022
  • 1 location
Comparative Analysis Between Sleeve Gastrectomy and Roux-en Y Gastric Bypass in Bariatric Operation

Prospective, double-arm, multi-center cohort study on obese patients, for laparoscopic sleeve gastrectomy versus Roux-en Y gastric bypass

  • 26 Jan, 2021
  • 1 location
Neurocognition After Perturbed Sleep (NAPS)

Individuals with schizophrenia display a wide range of neurocognitive difficulties resulting in functional impairment and disability. Extensive evidence indicates insomnia and sleep disturbances play a substantial role in degrading cognitive functioning. However, the putative impact of insomnia and sleep disturbances on neurocognition and daily functioning has not been investigated in …

schizophreniform disorder
  • 19 Apr, 2022
  • 1 location
Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia (R01)

The study is a three phase sequential study of the medical treatment of insomnia with zolpidem. All participating subjects will receive one month of standard nightly treatment. If the subject has a positive treatment response they continue in the study and are randomized to one of four conditions: intermittent dosing …

behavior therapy
cognitive therapy
cognitive behavioral therapy for insomnia
chronic insomnia
  • 04 Oct, 2022
  • 1 location
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary endpoint) and overall LH and follicle-stimulating hormone secretion (secondary endpoints).

  • 04 Oct, 2022
  • 1 location
Hyperandrogenemia and Altered Day-night LH Pulse Patterns (CRM008)

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone pulse frequency (primary endpoint).

luteinizing hormone
Accepts healthy volunteers
  • 29 May, 2022
  • 1 location
Understanding Trauma Nightmares Using In-Home Measurement

Trauma-related nightmares in Veterans are associated with poor clinical outcomes, greater substance use, and increased risk of suicide. In spite of an urgent need to reduce the burden of trauma-related nightmares, the underlying physiological changes associated with them are poorly understood, and there are no clear evidence-based recommendations for their …

substance use
  • 21 Mar, 2022
  • 1 location
Sleep and Emotional Memory in Peripubertal Anxiety

The current study aims to deepen understanding of the symptom dimension of negative overgeneralization in anxiety. Specifically, the study examines the malleability of memory processes that are known to occur during sleep that may underlie negative overgeneralization.

generalized anxiety
social phobia
separation anxiety
Accepts healthy volunteers
  • 11 Apr, 2023
  • 2 locations
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART) (KETOHEART)

The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the healthcare system. Numerous scientific evidences have demonstrated that a moderate weight loss (5-10% of the initial body weight) is …

Accepts healthy volunteers
  • 10 Apr, 2023
  • 1 location
Exercise and Sleep in Parkinson's Disease

This study will investigate the impact of two common exercise modalities, cardiovascular and resistance training, on sleep quality and architecture in persons with Parkinson's disease (PD), and whether these potential positive changes in sleep are associated with improvements in brain plasticity and different quality of life (QoL)-related aspects. Participants will …

Accepts healthy volunteers
  • 24 Apr, 2022
  • 1 location