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Found 109 clinical trials
Evaluation of An Optical Measurement Algorithm Combined With Patient and Provider Input to Reduce Mask Exchanges During Initial Positive Airway Pressure Therapy

Continuous positive airway pressure and non-invasive ventilation are common treatment modalities for obstructive sleep apnea, central sleep apnea, and chronic alveolar hypoventilation from a variety of causes. Use of positive airway pressure (PAP) requires use of an interface, commonly referred to as a "mask." There are a range of mask …

obstructive sleep apnea
apnea-hypopnea index
continuous positive airway pressure
central sleep apnea
  • 16 Oct, 2021
  • 1 location
Investigation of Sleep Quality and Prevalence of Sleep-disordered Breathing in Children and Young People With Epilepsy

Obstructive sleep apnoea (OSA) is a condition that affects around one in 20 children. In children with OSA, repeated episodes of airway obstruction can severely disturb and fragment sleep, leading to subsequent cognitive and behavioural problems . Epilepsy affects 60,000 children in the UK and up to 30% of children …

Accepts healthy volunteers
sleep disturbances
sleep-disordered breathing
  • 05 May, 2022
  • 1 location
Novel EEG Coherence Biomarkers for PTSD Assessment

Current practice for diagnosing and managing PTSD relies primarily on subjective clinical assessments by clinicians as well as patient self-report. An independent, objective and neuro-physiology based method for directly assessing brain function is not available, but is much needed to improve diagnosis and management of PTSD. To address this critical …

Accepts healthy volunteers
  • 12 Apr, 2022
  • 1 location
Impact of Breathing Route on CPAP Effectiveness to Treat Obstructive Sleep Apnea

To determine the impact of the CPAP route (oronasal vs oral) in patients diagnosed with moderate-severe OSA using CPAP with oronasal mask on CPAP level, residual AHI, and peak flow. In addition, the impact of position (lateral vs supine position) will be evaluated during PSG.

  • 10 May, 2022
Changes in Body Fat and Morphologic Characteristics Associated With OSA Resolution After Bariatric Surgery

Prospective study with inclusion of bariatric surgery candidates with diagnosed Obstructive Sleep Apnea and requiring treatment with Continuous Positive Air Pressure, aiming to evaluate at 2-6-12 months after bariatric surgery whether the relationship between biometric changes (reduction in neck circumference, height, waist/hip ratio, and fat and lean mass) and the …

  • 14 Jun, 2022
  • 1 location
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Obesity (BIOMIS-Endo)

This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with morbid obesity, metabolically healthy obesity and from healthy volunteers. Microbiota is a complex consortium of microorganisms, located at the mucosal level (in particular intestinal, oral and vaginal) having a key role in …

Accepts healthy volunteers
morbid obesity
  • 21 Mar, 2022
  • 1 location
Natural History of Pompe Disease (POMPE)

The project is a prospective study in which patients affected by adult-onset Pompe disease with c.-32-13T>G mutation in the GAA gene will be followed-up during two years to describe the natural history using clinical, imaging, histological and molecular parameters. Secondary objectives are: To identify biomarkers for assessing efficacy of future …

gaa gene
walk test
  • 02 May, 2022
  • 1 location
Wearable Remote Monitoring of Heart Rate and Respiratory Rate for Heart Failure

The primary objective of this study is to study in heart failure (HF) patients to better assess HF disease state, which can aid in management and improve outcomes. Primary aims of the study include: (1) Measure HR and RR at rest and during daily activity using the WHOOP device. (2) …

Accepts healthy volunteers
acute heart failure
heart failure
  • 02 Dec, 2021
  • 1 location
Long-term Follow-up of Children With OSA Treated With AT

Objectives: To assess the cardiovascular outcomes of children with obstructive sleep apnoea (OSA) at a mean of 5 years after they had undergone adenotonsillectomy (AT), compared to OSA children who did not undergo AT, and normal controls without OSA. Hypothesis to be tested: (1) children with OSA underwent AT would …

  • 29 Aug, 2021
  • 1 location