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Found 55 clinical trials
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Myelofibrosis

Myelofibrosis

  • 532 views
  • 08 Nov, 2020
  • 1 location
The TAPS Trial - Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence

with twin anemia-polycythemia sequence. Half op the patients will be treated with fetoscopic laser surgery, while the other half will be managed with standard treatment. The hypothesis is that

  • 0 views
  • 25 Jan, 2021
  • 4 locations
MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polcythemia Vera

The trial will be a phase III, randomised-controlled, multi-centre, international, open-label trial consisting of ruxolitinib versus best available therapy, where best available therapy is a choice of interferon alpha, any formulation permitted (IFN) or hydroxycarbamide (HC), and which will be elected by the Investigator prior to randomisation.

hydroxyurea
interferon
ruxolitinib
  • 0 views
  • 24 Jan, 2021
  • 2 locations
Hepcidin Mimetic in Patients With Polycythemia Vera

and to obtain preliminary evidence of efficacy of PTG-300 for the treatment of phlebotomy-requiring polycythemia vera.

hydroxyurea
interferon
phlebotomy
ruxolitinib
  • 8 views
  • 26 Jan, 2021
  • 17 locations
Clinical Efficacy of Erythropheresis in High Altitude Polycythemia

The clinical study is aimed to explore the efficacy and safety of erythropheresis in high altitude polycythemia.

  • 0 views
  • 08 Apr, 2021
  • 1 location
PTG-300 in Patients With Polycythemia Vera and Elevated Hematocrit

This is an open label, single arm trial of PTG-300 in subjects with PV who are newly diagnosed or for whom current therapy is not sufficient to control their hematocrit and have hematocrit >48% prior to dosing. The PTG-300 dose and schedule may be adjusted every 2 to 4 weeks …

  • 0 views
  • 11 Mar, 2021
  • 5 locations
Erythropoietin in Premature Infants to Prevent Encephalopathy

The main goal of this trial is to investigate whether early administration of human erythropoietin (EPO) in preterm infants improves neurodevelopmental outcome at 18 months corrected age. This study is designed as randomized, double-masked, placebo controlled multicenter study involving at least 312 patients.

  • 0 views
  • 15 Mar, 2021
  • 1 location
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis Post Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis

) Condition or disease: Primary Myelofibrosis/Post-Polycythemia Vera Myelofibrosis/ Post-essential Thrombocythemia Myelofibrosis Intervention/treatment: Drug-Pacritinib

essential thrombocythemia
neutrophil count
direct bilirubin
thrombocytosis
renal function
  • 506 views
  • 09 May, 2021
  • 176 locations
A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Patients (MOMENTUM)

effectiveness and safety of MMB to DAN in treating and reducing: 1) disease related symptoms, 2) the need for blood transfusions and 3) splenomegaly, in adults with primary MF, post-polycythemia vera MF or post

essential thrombocythemia
neutrophil count
direct bilirubin
extramedullary hematopoiesis
thrombocytosis
  • 249 views
  • 13 Apr, 2021
  • 232 locations
An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis Post-polycythemia Vera Myelofibrosis or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

Prognostic Scoring System)-intermediate or high-risk primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (post-PV MF), or post-essential thrombocythemia myelofibrosis (post-ET MF) and

cancer
essential thrombocythemia
thrombocytosis
fedratinib
anemia
  • 103 views
  • 17 Apr, 2021
  • 125 locations